Propanoic acid--4,5-difluoro-1H-indole (1/1)

Base Information

Chemical Name:Propanoic acid--4,5-difluoro-1H-indole (1/1)
CAS No.:194870-66-1
Molecular Formula:C11H9F2NO2
Molecular Weight:227.20700
Hs Code.:
DSSTox Substance ID:DTXSID40693859
Mol file:194870-66-1.mol

Synonyms:DTXSID40693859;AKOS015904215;Propanoic acid--4,5-difluoro-1H-indole (1/1)

Suppliers and Price of Propanoic acid--4,5-difluoro-1H-indole (1/1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl4,5-Difluoro-1H-indole-2-carboxylate
100mg
$ 330.00

Crysdot
Ethyl4,5-difluoro-1H-indole-2-carboxylate 95+%
1g
$ 668.00

Chemenu
Ethyl4,5-difluoro-1H-indole-2-carboxylate 95%
1g
$ 631.00

American Custom Chemicals Corporation
4,5-DIFLUOROINDOLE-2-ETHYLCARBOXYLATE 95.00%
5MG
$ 501.01

Alichem
Ethyl4,5-difluoro-1H-indole-2-carboxylate
1g
$ 544.00

Total 9 raw suppliers

Chemical Property of Propanoic acid--4,5-difluoro-1H-indole (1/1)

Chemical Property:

PSA：53.09000
LogP:2.92710
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:227.07578492
Heavy Atom Count:16
Complexity:191

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4,5-Difluoro-1H-indole-2-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=O)O.C1=CC(=C(C2=C1NC=C2)F)F

Technology Process of Propanoic acid--4,5-difluoro-1H-indole (1/1)

There total 4 articles about Propanoic acid--4,5-difluoro-1H-indole (1/1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 617-35-6
2-oxo-propionic acid ethyl ester

: 40594-37-4,875664-54-3
(3,4-difluorophenyl)phenylhydrazine hydrochloride

: 194870-66-1
ethyl 4,5-difluoro-1H-indole-2-carboxylate

: 169674-34-4
ethyl 5,6-difluoro-1H-indole-2-carboxylate

Guidance literature:: 2-oxo-propionic acid ethyl ester; (3,4-difluorophenyl)phenylhydrazine hydrochloride; In ethanol; for 12h; Reflux;

With phosphoric acid; In ethanol; at 75 - 80 ℃; for 0.166667h; Overall yield = 4.98 g;

Reference yield:

: 609-14-3
2-acetylpropanoic acid ethyl ester

: 3863-11-4
3,4-difluoroaniline

: 194870-66-1
ethyl 4,5-difluoro-1H-indole-2-carboxylate

: 169674-34-4
ethyl 5,6-difluoro-1H-indole-2-carboxylate

Guidance literature:: 3,4-difluoroaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.666667h;

With sodium acetate; In water; for 0.5h;

2-acetylpropanoic acid ethyl ester; With potassium acetate; more than 3 stages;

Reference yield:

2-methylacetoacetic ester: 2-methylacetoacetic ester

: ethyl acetate n-hexane

: 3863-11-4
3,4-difluoroaniline

: 194870-66-1
ethyl 4,5-difluoro-1H-indole-2-carboxylate

Guidance literature:: With hydrogenchloride; potassium hydroxide; p-toluenesulfonic acid monohydrate; isopentyl nitrite; In ice-water; ethanol;