19491-57-7

Basic information

• Product Name: dimethyl (1R*,2S*,5R*)-5-methyl-cyclohexane-1,2-dicarboxylate
• CAS NO: 19491-57-7
• Molecular Weight: 214.262
• Mol File: 19491-57-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dimethyl (1R*,2S*,5R*)-5-methyl-cyclohexane-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl (1R*,2S*,5R*)-5-methyl-cyclohexane-1,2-dicarboxylate(19491-57-7)
• EPA Substance Registry System: dimethyl (1R*,2S*,5R*)-5-methyl-cyclohexane-1,2-dicarboxylate(19491-57-7)

Safety Data

• Hazardous Substances Data: 19491-57-7(Hazardous Substances Data)

Upstream product

• 1694-82-2 cis-3a,4,7,7a-tetrahydro-5-methyl-1,3-isobenzofurandione 
• 106552-43-6 (Z)-9-hydroxy-4-methyl-7-nonenoic acid lactone 
• 106542-15-8 5-methyl-2-ethenylcyclohexanecarboxylic acid 
• 106540-63-0 (Z)-9-hydroxy-4-methyl-7-nonenoic acid 
• 186581-53-3 diazomethane 
• 57567-84-7 (+/-)-4c-methyl-cyclohexane-1r,2c-dicarboxylic acid 

Downstream Products

• 19438-60-9 (+/-)-4t-methyl-cyclohexane-1r,2t-dicarboxylic acid-anhydride 
• 57567-84-7 (+/-)-4t-methyl-cyclohexane-1r,2t-dicarboxylic acid 

Relevant articles and documents

CLAISEN-REARRANGEMENT-MEDIATED RING CONTRACTION OF MACROCYCLIC LACTONES A NEW APPROACH TO CARBOCYCLES AND HETEROCYCLES

Macrocyclic ketene acetals 3 undergo Claisen rearrangements smoothly and constitute a viable and general approach to hetero- or carbocyclic ring systems 4.This novel ring contraction process is subject to high internal asymmetric induction (cf. lactones 7 -> carbocycles 8) as well as relative asymmetric induction in the rearrangements of ketene acetals derived from lactones 18, 23 and 27.Finally, N-benzoylmeroquinene methyl ester (37) was prepared to demonstrate the potential of this methodology in heterocycle synthesis.