19492-61-6

Basic information

• Product Name: 4-(4-dimethylaminophenyl)-6-methyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester
• Synonyms: 4-(4-dimethylaminophenyl)-6-methyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester;ethyl 4-(4-dimethylaminophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate;ethyl 4-(4-dimethylaminophenyl)-6-methyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxylate;ethyl 4-[4-(dimethylamino)phenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS NO: 19492-61-6
• Molecular Formula: C₁₆H₂₁N₃O₂S
• Molecular Weight: 319.43
• Mol File: 19492-61-6.mol
• Article Data: 36

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-dimethylaminophenyl)-6-methyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-dimethylaminophenyl)-6-methyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester(19492-61-6)
• EPA Substance Registry System: 4-(4-dimethylaminophenyl)-6-methyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester(19492-61-6)

Safety Data

• Hazardous Substances Data: 19492-61-6(Hazardous Substances Data)

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 141-97-9 ethyl acetoacetate 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 4433-85-6 2-ethyl-3-oxobutanoic acid 
• 17356-08-0 thiourea 

Downstream Products

• 1402085-59-9 (E)-4-(4-dimethylaminophenyl)-6-(4-dimethylaminostyryl)-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid 
• 1315248-26-0 ethyl 3-methyl-5-(4-dimethylaminophenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1122513-43-2 ethyl 6-[4-(dimethylamino)phenyl]-1-formyl-4-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 635292-05-6 ethyl 3-amino-2-cyano-5-(4-(dimethylamino)phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 359452-44-1 ethyl 4-(4-(dimethylamino)phenyl)-6-methyl-2-(methylthio)-1,4-dihydropyrimidine-5-carboxylate 

Relevant articles and documents

Poly(N-vinyl-2-pyrrolidone)-supported ferric chloride: An effective reusable heterogeneous catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via three-component Biginelli reaction

An environmentally benign three-component Biginelli protocol for the one-pot synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones/thiones using an accessible, nontoxic, easy to handle, and recoverable macromolecular Lewis acidic catalyst is developed.

1-Methyl-2-oxopyrrolidinium perchlorate ionic liquid in synthesis of 5-ethoxycarbonyl-3,4-dihydropyrimidin-2(1H)-ones

A multicomponent Biginelli reaction in a solvent-free conditions catalyzed by 1-methyl-2-oxopyrrolidinium perchlorate ionic liquid was studied. The сondensation of aromatic aldehydes, urea (thiourea), and acetoacetic ester yielded substituted 5-ethoxycarb

Synthesis of a novel sterically hindered chiral cyclic phosphoric acid derived from L-tartaric acid and application to the asymmetric catalytic Biginelli reaction

A novel sterically hindered chiral cyclic phosphoric acid derived from L-tartaric acid was designed and synthesized based on highly regioselective cyclosulfitation of chiral 1,1,4,4-tetraphenylbutanetetraol. The asymmetric Biginelli reaction catalyzed by