194922-77-5Relevant academic research and scientific papers
An external chiral ligand controlled enantioselective opening of oxirane and oxetane by organolithiums
Mizuno, Masashi,Kanai, Motomu,Iida, Akira,Tomioka, Kiyoshi
, p. 10699 - 10708 (1997)
Enantioselective nucleophilic opening reactions of cyclohexene oxide and 3-phenyloxetane were achieved by the combination of an external chiral ligand and organolithiums in the presence of boran trifluoride to give the corresponding alcohols in up to 47% ee.
Catalytic asymmetric bromine-lithium exchange: A new tool to build axial chirality
Perron, Quentin,Alexakis, Alexandre
supporting information; experimental part, p. 2611 - 2620 (2011/01/05)
We present here the first catalytic desymmetrization of the 2,2′,6,6′-tetrabromobiphenyl 1 and analogues, by a bromine-lithium exchange catalyzed by either diamines or diether derivatives (0.5 equiv.), yielding axially chiral compounds in high yield (up to 89%) and high enantioselectivity (up to 82%).
