194925-84-3

Usage

Uses

Used in Medicinal Chemistry Research:
2H-Pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione, 4-methyl-2-(phenylmethyl)-, (4S)is used as a research compound for investigating its potential pharmacological activity and exploring its applications in medicinal chemistry.
Used in Drug Development:
2H-Pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione, 4-methyl-2-(phenylmethyl)-, (4S)is used as a candidate molecule for drug development, with the aim of discovering new therapeutic agents based on its unique structure and potential biological effects.

Upstream product

• 118-92-3 anthranilic acid 
• 132871-10-4 (3S)-1-benzyl-3-methylpiperazine-2,5-dione 

Downstream Products

• 194925-99-0 (1R,4S)-2-Benzyl-4-methyl-1-(4-methyl-benzyl)-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione 
• 194926-01-7 (1S,4S)-2-Benzyl-4-methyl-1-(4-methyl-benzyl)-1,2-dihydro-2,4a,9-triaza-anthracene-3,10-dione 

Relevant academic research and scientific papers

Intramolecular friedel-crafts-type reactions involving N-acyliminium ions derived from glycine templates

Enantiomerically pure 4-substituted 2-aralkyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-diones (1b-m) in which the alkyl chain is (CH2)n, n = 1-3, behave as glycine templates giving by treatment with [hydroxy(tosyloxy)iodo]benzene in ethyl acetate cis-1-tosyloxy derivatives. When these compounds contain electron-rich aryl substituents with n = 2, they spontaneously cyclize through intramolecular Friedel-Crafts-type diastereoselective reactions to give penta- or hexacyclic compounds. Otherwise, they give by solvolysis cis-1-alkoxy derivatives, which in a second step, may be cyclized in acid if n = 2, 3. All these reactions must occur through N-acyliminium species in SN1-like mechanisms. 1-Alkoxy-2-arylmethyl derivatives are reluctant to cyclize, giving trans-1-hydroxy compounds as the only isolated reaction products.