194935-38-1

Usage

Uses

Used in Pharmaceutical Industry:
DINOPROSTONE ETHANOLAMIDE is used as a therapeutic agent for various medical conditions due to its agonistic activity at EP receptors and its ability to inhibit IDO-1. Its application includes the treatment of inflammation, pain, and potentially other conditions related to prostaglandin signaling pathways.
Used in Inflammation and Pain Management:
DINOPROSTONE ETHANOLAMIDE is used as an anti-inflammatory and analgesic agent for managing pain and inflammation, taking advantage of its ability to modulate prostaglandin signaling pathways and inhibit IDO-1.
Used in Research Applications:
DINOPROSTONE ETHANOLAMIDE is used as a research tool for studying the roles of prostaglandins, their receptors, and related signaling pathways in various biological processes and disease conditions. Its application in research helps to advance the understanding of prostaglandin biology and develop new therapeutic strategies.
Used in Drug Development:
DINOPROSTONE ETHANOLAMIDE serves as a lead compound in the development of new drugs targeting prostaglandin pathways, potentially leading to the creation of novel therapeutics for a range of conditions, including inflammation, pain, and other prostaglandin-related disorders.

Upstream product

• 398138-27-7 prostaglandin H₂ 1-ethanolamide 9,11-cycloendoperoxide 
• 363-24-6 dinoprostone 
• 141-43-5 ethanolamine 

Relevant academic research and scientific papers

A Unique Collision-Induced Dissociation Reaction of Cholamine Derivatives of Certain Prostaglandins

Prostaglandins (PGs) are biologically active metabolites of arachidonic acid containing 20 carbon atoms, a cyclic moiety, and two side chains (A and B) in common. The bioassay of PGs requires high sensitivity because of their low concentration in tissues and blood and has usually been carried out by electrospray ionization tandem mass spectrometry (ESI-MS/MS) in the negative ion mode. Chemical derivatization of PG carboxylic acid groups to introduce positive charge-carrying groups is an established strategy to improve the sensitivity and selectivity of such assays. In this study, we exploited this approach for structural identification of a series of PGs using cholamine derivatization through an amidation reaction. However, we observed that collision-induced dissociation of these derivatives gave rise to unexpected product ions that we postulated were formed by unique long-range intramolecular reactions resulting in dehydration of the B chain accompanied by fragmentation of the A chain through an unusual Hofmann rearrangement. Evidence for the proposed mechanism is presented based on ESI-MS/MS and high resolution mass spectrometry studies of cholamine derivatives of PGE1, PGE2, PGD2, PGI2, and C-17 methyl deuterium-labeled limaprost. [Figure not available: see fulltext.].

9,11-cycloendoperoxide pro-drugs of prostaglandin analogues for treatment of ocular hypertension and glaucoma

9,11-Cycloendoperoxide derivatives of biologically active prostaglandin analogs, and particularly of the ocular hypotensive drugs Bimatoprost, Latanaprost, Unoprostone, Travoprost and prostaglandin H2 1-ethanolamide or of structurally closely related analogs, are pro-drugs which hydrolyze under physiological conditions to provide prostaglandin analogues that are capable of providing sustained ocular and other in vivo concentrations of the respective drugs. The compounds of the invention have the formula shown below where the variables have the meaning defined in the specification.