194985-34-7

Basic information

• Product Name: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-D-phenylalanyl-, methyl ester
• CAS NO: 194985-34-7
• Molecular Formula: C21H30N2O5
• Molecular Weight: 390.48
• Mol File: 194985-34-7.mol

Chemical Properties

• CAS DataBase Reference: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-D-phenylalanyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-D-phenylalanyl-, methyl ester(194985-34-7)
• EPA Substance Registry System: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-D-phenylalanyl-, methyl ester(194985-34-7)

Safety Data

• Hazardous Substances Data: 194985-34-7(Hazardous Substances Data)

Upstream product

• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 37553-65-4 N-tert-butoxycarbonyl-N-methyl-D-phenylalanine 
• 2133-40-6 L-proline methyl ester monohydrochloride 

Downstream Products

• 911408-05-4 C₂HF₃O₂*C₁₆H₂₂N₂O₃ 
• 1071815-02-5 C₂₄H₃₆N₄O₅ 
• 1071814-98-6 Boc-Ile-Gly-N-Me-D-Phe-Pro-OM 
• 1071814-97-5 C₁₈H₂₅N₃O₄ 
• 1071814-96-4 C₃₃H₃₅N₃O₆ 
• 911408-04-3 C₁₆H₂₂N₂O₃ 
• 1415033-96-3 C₄₃H₆₁N₇O₁₀ 
• 1415033-95-2 C₃₈H₅₃N₅O₈ 

Relevant articles and documents

Design, synthesis and biological evaluation of tasiamide analogues as tumor inhibitors

Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. Th

Total synthesis of grassystatin A, a probe for cathepsin e function

The linear depsipeptide grassystatin A, a valuable probe for the study of cathepsin E function, has been synthesized by a [4+6] strategy. It exhibited specific inhibitory activity against cathepsin E with an IC50 value of 0.8 nM. Our studies in

Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases

Inspired by marine cyanobacterial natural products, we synthesized modified peptides with a central statine-core unit, characteristic for aspartic protease inhibition. A series of tasiamide B analogues inhibited BACE1, a therapeutic target in Alzheimer's

Total synthesis and stereochemical reassignment of tasiamide B

The first total synthesis of tasiamide B, an octapeptide bearing 4-amino-3-hydroxy-5-phenylpentanoic acid unit isolated from the marine cyanobacteria Symploca sp. is described. A simple and efficient way was found to avoid the pyroglutamylation of Nα-Me-Gln and led to a reassignment of the Nα-Me-L-Phe of tasiamide B to be N α-Me-D-Phe, which was also supported by 1D and 2D NMR. Copyright