911408-04-3Relevant academic research and scientific papers
Total synthesis and stereochemical reassignment of maedamide
Takayanagi, Ayano,Iwasaki, Arihiro,Suenaga, Kiyotake
, p. 4947 - 4949 (2015)
Abstract The first total synthesis of maedamide, an acyclic peptide isolated from a marine cyanobacterial assemblage of Lyngbya sp., was achieved. This synthesis led to reassignment of the allo-d-Ile of maedamide to be l-Ile, which was supported by 1
Design, synthesis and biological evaluation of tasiamide analogues as tumor inhibitors
Zhang, Wei,Sun, Tiantian,Ma, Zhenhua,Li, Yingxia
, p. 2308 - 2325 (2014/06/09)
Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. Th
Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases
Liu, Yanxia,Zhang, Wei,Li, Li,Salvador, Lilibeth A.,Chen, Tiantian,Chen, Wuyan,Felsenstein, Kevin M.,Ladd, Thomas B.,Price, Ashleigh R.,Golde, Todd E.,He, Jianhua,Xu, Yechun,Li, Yingxia,Luesch, Hendrik
, p. 10749 - 10765 (2013/02/23)
Inspired by marine cyanobacterial natural products, we synthesized modified peptides with a central statine-core unit, characteristic for aspartic protease inhibition. A series of tasiamide B analogues inhibited BACE1, a therapeutic target in Alzheimer's
