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(3-Nitrobenzyl)methylamine, also known as N-Methyl-3-nitrobenzylamine, is an organic compound that serves as a crucial intermediate in various chemical syntheses. It is characterized by its nitrobenzyl group attached to a methylamine moiety, which provides it with unique reactivity and properties that make it valuable in the production of different compounds.

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  • 19499-61-7 Structure
  • Basic information

    1. Product Name: (3-Nitrobenzyl)methylamine
    2. Synonyms: 3-Nitro-N-methylbenzylamine;N-Methyl-N-(3-nitrobenzyl)amine ,97%;(3-Nitrobenzyl)methy;N-Methyl-3-nitrobenzylaMine, 95%;N-Methyl-1-(3-nitrophenyl)MethanaMine;(3-Nitrobenzyl)MethylaMine, 98%+;N-METHYL-N-(3-NITROBENZYL)AMINE;(3-NITROBENZYL)METHYLAMINE
    3. CAS NO:19499-61-7
    4. Molecular Formula: C8H10N2O2
    5. Molecular Weight: 166.18
    6. EINECS: N/A
    7. Product Categories: Polyamines
    8. Mol File: 19499-61-7.mol
  • Chemical Properties

    1. Melting Point: 160 °C
    2. Boiling Point: 128 °C
    3. Flash Point: 119.7 °C
    4. Appearance: /Oil
    5. Density: 1.162 g/cm3
    6. Vapor Pressure: 0.00546mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
    9. Solubility: N/A
    10. PKA: 8.94±0.10(Predicted)
    11. Water Solubility: Slightly soluble in water.
    12. CAS DataBase Reference: (3-Nitrobenzyl)methylamine(CAS DataBase Reference)
    13. NIST Chemistry Reference: (3-Nitrobenzyl)methylamine(19499-61-7)
    14. EPA Substance Registry System: (3-Nitrobenzyl)methylamine(19499-61-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: 8
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 19499-61-7(Hazardous Substances Data)

19499-61-7 Usage

Uses

Used in Organic Synthesis:
(3-Nitrobenzyl)methylamine is used as an important intermediate for the synthesis of various organic compounds. Its versatile chemical structure allows it to be a key component in the creation of a wide range of molecules.
Used in Agrochemicals:
In the agrochemical industry, (3-Nitrobenzyl)methylamine is used as a vital raw material for the development of new pesticides and other agricultural chemicals. Its incorporation into these products helps improve their effectiveness and selectivity, contributing to more efficient and environmentally friendly agricultural practices.
Used in Pharmaceutical Industry:
(3-Nitrobenzyl)methylamine plays a significant role in the pharmaceutical industry as a building block for the synthesis of various drugs. Its unique structure can be manipulated to create molecules with specific biological activities, making it a valuable asset in the development of new medications.
Used in Dye Industry:
(3-Nitrobenzyl)methylamine is also utilized in the dyestuff industry as a starting material for the production of different types of dyes. Its chemical properties enable the creation of dyes with specific color characteristics and stability, which are essential for various applications, including textiles, plastics, and printing inks.

Check Digit Verification of cas no

The CAS Registry Mumber 19499-61-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,4,9 and 9 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 19499-61:
(7*1)+(6*9)+(5*4)+(4*9)+(3*9)+(2*6)+(1*1)=157
157 % 10 = 7
So 19499-61-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2O2/c1-9-6-7-3-2-4-8(5-7)10(11)12/h2-5,9H,6H2,1H3/p+1

19499-61-7 Well-known Company Product Price

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  • (Code)Product description
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  • Alfa Aesar

  • (H63942)  N-Methyl-3-nitrobenzylamine, 95%   

  • 19499-61-7

  • 1g

  • 377.0CNY

  • Detail
  • Alfa Aesar

  • (H63942)  N-Methyl-3-nitrobenzylamine, 95%   

  • 19499-61-7

  • 5g

  • 1509.0CNY

  • Detail

19499-61-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (3-Nitrobenzyl)methylamine

1.2 Other means of identification

Product number -
Other names N-Methyl-1-(3-nitrophenyl)methanamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19499-61-7 SDS

19499-61-7Relevant articles and documents

Installation of Pargyline, a LSD1 Inhibitor, in the HDAC Inhibitory Template Culminated in the Identification of a Tractable Antiprostate Cancer Agent

Chen, I-Chung,Chen, Mei-Chuan,Hsieh, Chien-Ming,Hsu, Kai-Cheng,Lai, Row-Wen,Lin, Tony Eight,Liou, Jing-Ping,Nepali, Kunal,Ojha, Ritu,Pan, Shiow-Lin

, p. 17824 - 17845 (2022/01/03)

Pragmatic insertion of pargyline, a LSD1 inhibitor, as a surface recognition part in the HDAC inhibitory pharmacophore was planned in pursuit of furnishing potent antiprostate cancer agents. Resultantly, compound 14 elicited magnificent cell growth inhibi

Novel chiral bis-phosphoramides as organocatalysts for tetrachlorosilane-mediated reactions

Rossi, Sergio,Ziliani, Marco,Annunziata, Rita,Benaglia, Maurizio

supporting information, (2018/01/12)

The formation of novel chiral bidentate phosphoroamides structures able to promote Lewis base-catalyzed Lewis acid-mediated reactions was investigated. Two different classes of phosphoroamides were synthetized: the first class presents a phthalic acid/pri

Phenyl ether- and aniline-containing 2-aminoquinolines as potent and selective inhibitors of neuronal nitric oxide synthase

Cinelli, Maris A.,Li, Huiying,Pensa, Anthony V.,Kang, Soosung,Roman, Linda J.,Martásek, Pavel,Poulos, Thomas L.,Silverman, Richard B.

supporting information, p. 8694 - 8712 (2015/11/25)

Excess nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS) is implicated in neurodegenerative disorders. As a result, inhibition of nNOS and reduction of NO levels is desirable therapeutically, but many nNOS inhibitors are poorly bioavailable. Promising members of our previously reported 2-aminoquinoline class of nNOS inhibitors, although orally bioavailable and brain-penetrant, suffer from unfavorable off-target binding to other CNS receptors, and they resemble known promiscuous binders. Rearranged phenyl ether- and aniline-linked 2-aminoquinoline derivatives were therefore designed to (a) disrupt the promiscuous binding pharmacophore and diminish off-target interactions and (b) preserve potency, isoform selectivity, and cell permeability. A series of these compounds was synthesized and tested against purified nNOS, endothelial NOS (eNOS), and inducible NOS (iNOS) enzymes. One compound, 20, displayed high potency, selectivity, and good human nNOS inhibition, and retained some permeability in a Caco-2 assay. Most promisingly, CNS receptor counterscreening revealed that this rearranged scaffold significantly reduces off-target binding.

SULPHONAMIDE DERIVATIVES OF BENZYLAMINE FOR THE TREATMENT OF CNS DISEASES

-

Paragraph 0519-0520, (2015/02/25)

Sulphonamide derivatives of benzylamine of formula (I), wherein A represents phenyl unsubstituted or substituted; or 9- or 10-membered bicyclic group, linked to —(O)x—(CH2)y— through one of its aromatic carbon atoms, consisting of benzene ring fused with -membered heteroaromatic ring containing 1 or 2 heteroatoms independently selected from the group consisting of N and O, wherein such bicyclic group is unsubstituted or substituted or with 5- or 6-membered non-aromatic heterocyclic ring having 1 or 2 O atoms, wherein heterocyclic ring is unsubstituted or substituted with one or more C1-C3-alkyls; D represents a group selected from: phenyl unsubstituted or substituted; naphthyl unsubstituted or substituted; thiophene unsubstituted or substituted; bicyclic group consisting of imidazolering fused with 5-membered non-aromatic carbocyclic ring; bicyclic group consisting of benzene ring fused with 5-membered heteroaromatic ring, having 1 or 2 heteroatoms independently selected from the group consisting of N, O and S, unsubstituted or substituted and linked to sulphonamide moiety through one of carbon atoms of benzene ring; and bicyclic group consisting of benzene ring fused with—or 6-membered non-aromatic heterocyclic ring having 1 or 2 heteroatoms independently selected from the group consisting of N and O, unsubstituted or substituted, and linked to sulphonamide moiety through one of carbon N atoms of benzene ring; R represents H or —CH 3; x is 0 or 1; y is 2 or 3; and pharmaceutically acceptable salts and solvates thereof, with the provisos that if x is 0 and y is 2, then D is naphthyl unsubstituted or substituted with one halogen atom, and if R represents —CH 3, then A is not unsubstituted or substituted phenyl. The compounds can be used in the treatment and/or prophylaxis of central nervous system disorders.

SULPHONAMIDE DERIVATIVES OF BENZYLAMINE FOR THE TREATMENT OF CNS DISEASES

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Page/Page column 48-49, (2013/10/08)

Sulphonamide derivatives o f benzylamine of formula (I), wherein A represents phenyl unsubstituted or substituted;or 9-or 10-membered bicyclic group, linked to -(O)x - (CH2)y -through one of its aromatic carbon atoms, consisting of benzene ring fused with -membered heteroaromatic ring containing 1 or 2 heteroatoms independently selected from the group consisting of N and O, wherein such bicyclic group is unsubstituted or substituted or with 5-or 6-membered non-aromaticheterocyclic ring having 1 or 2 O atoms, wherein heterocyclic ring is unsubstituted or substituted with one or more C1-C3 - alkyls; D represents a group selected from:phenyl unsubstituted or substituted; naphthyl unsubstituted or substituted;thiophene unsubstituted or substituted;bicyclic group consisting of imidazolering fused with5-membered non-aromatic carbocyclic ring; bicyclic group consisting of benzene ring fused with 5-membered heteroaromatic ring, having 1 or 2heteroatoms independently selected from the group consisting of N, O and S, unsubstituted or substituted and linked to sulphonamide moiety through one of carbon atoms of benzene ring;and bicyclic group consisting of benzene ring fused with -or 6-membered non-aromatic heterocyclic ring having 1 or 2heteroatoms independently selected from the group consisting of N and O, unsubstituted or substituted, and linked to sulphonamide moiety through one of carbon atoms of benzene ring;R represents H or -CH3;x is 0 or 1 ;yis 2 or 3;and pharmaceutically acceptable salts and solvates thereof, with the provisos that if x is 0 and y is 2, then D is naphthyl unsubstituted or substituted with one halogen atom, and if R represents -CH3, then A is not unsubstituted or substituted phenyl. The compounds can be used in the treatment and/or prophylaxis of central nervous system disorders

DERIVATIVES OF 4-(2-AMINO-1-HYDROXIETHYL)PHENOL AS AGONISTS OF THE β2 ADRENERGIC RECEPTOR

-

Page/Page column 29-30, (2008/06/13)

This invention is directed to compounds of formula (I): to pharmaceutical compositions comprising them; to combination products comprising them; and to their use in therapy.

QUINAZOLINE DERIVATIVES FOR USE AGAINST CANCER

-

Page/Page column 104, (2008/06/13)

The invention concerns quinazoline derivatives of Formula (I) or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of p, R1, q, R2, R3, R4, R5, Ring A, X1, R6, r and R7 has any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders or in the treatment of disease states associated with angiogenesis and/or vascular permeability.

Assessment of a reductive amination route to methyl(3-nitrobenzyl)amine hydrochloride

Connolly, Terrence J.,Constantinescu, Anton,Lane, Tim S.,Matchett, Michael,McGarry, Patrick,Paperna, Mariya

, p. 837 - 842 (2012/12/26)

During the development of a sodium borohydride mediated reductive animation of 3-nitrobenzaldehyde with methylamine, studies revealed that partial reduction of the nitro group occurred, and potentially dangerous azo- and azoxy-containing products were gen

AMINE COMPOUNDS

-

Page 188, (2010/02/07)

The present invention provide a compound of the formula:wherein ring A represents an aromatic ring optionally having substituents; B, Y and Ya are the same or different and each represents a bond, etc.; R1 and R2 are the same or different and each represents a hydrogen atom, etc.; R3 represents a hydrogen atom, etc.; R4 and R5 are the same or different and each represents a hydrogen, etc.; R6 represents an indolyl group optionally having substituents; and Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibition activity and is useful for preventing and/or treating diseases associated with somatostatin.

Aniline derivatives possessing an inhibitory effect of nitric oxide synthase

-

, (2008/06/13)

Compounds represented by the general formula (1): ? (where R1is SR6or NR7R8, where R6is typically an alkyl group having 1-6 carbon atoms, R7is a hydrogen atom, an alkyl group having 1-6 carbon atoms or a nitro group, and R8is a hydrogen atom or an alkyl group having 1-6 carbon atoms; R2and R3are each typically a hydrogen atom or an alkyl group having 1-6 carbon atoms; R4is a hydrogen atom, an alkyl group having 1-6 carbon atoms or an amidino group of which the amine portion may be substituted by an alkyl or nitro group; R5is a hydrogen atom or an alkyl group having 1-6 carbon atoms; Y1, Y2, Y3and Y4which may be the same or different are each typically a hydrogen atom, a halogen atom or an alkoxy group having 1-6 carbon atoms; n and m are each an integer of 0 or 1), or possible stereoisomers or optically active forms of the compounds or pharmaceutically acceptable salts thereof. The compounds possess a potent nitric oxide synthase inhibiting activity and are useful as therapeutics of cerebrovascular diseases.

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