194995-44-3Relevant academic research and scientific papers
THERAPEUTIC COMPOUNDS AND COMPOSITIONS
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, (2015/09/22)
The present invention provides compounds and compositions that inhibit Factor XIa or kallikrein and methods of using these compounds and composition.
Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems
Lin, Yang-I.,Bitha, Panayota,Li, Zhong,Sakya, Subas M.,Strohmeyer, Timothy W.,Lang Jr., Stanley A.,Yang, Youjun,Bhachech, Niraja,Weiss, William J.,Petersen, Peter J.,Jacobus, Nilda V.,Bush, Karen,Testa, Raymond T.
, p. 1811 - 1816 (2007/10/03)
Mono and bis double ester prodrugs of aminomethyl THF 1β-methylcarbapenems 1 were Mono double ester derivatives (2, 4 and 7) did not demonstrate significantly improved oral activity due to the presence of the charged species. However, bis double ester derivatives (3 and 5) demonstrated enhanced oral activity.
