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3,3,7-Trimethyloxindole, commonly known as skatole, is a chemical compound with the molecular formula C9H9NO. It is a white crystalline solid that possesses a strong, foul odor. Skatole is naturally produced as a byproduct of bacterial metabolism in feces and is also utilized in the fragrance and flavor industry to create a scent reminiscent of natural animal musk. Its potential role in biological processes, including as a biomarker for certain diseases, has been a subject of study. However, high levels of exposure to skatole can be detrimental to human health, leading to irritation of the eyes, nose, throat, and causing respiratory and gastrointestinal problems.

19501-89-4

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19501-89-4 Usage

Uses

Used in Fragrance and Flavor Industry:
3,3,7-Trimethyloxindole is used as a scent compound in the fragrance and flavor industry for its ability to produce a musk-like aroma, which is similar to that of natural animal musk. This application takes advantage of its strong odor profile to create unique and desirable scents in various products.
Used in Research and Development:
In the scientific community, 3,3,7-Trimethyloxindole is used as a research chemical for studying its potential role in biological processes. It is particularly valuable in investigations aimed at identifying it as a biomarker for certain diseases, which could lead to advancements in diagnostic techniques and treatments.
Used in Environmental and Health Studies:
3,3,7-Trimethyloxindole is also utilized in environmental and health studies to understand the effects of exposure to high levels of the compound. This research is crucial for establishing safety guidelines and regulations to protect human health and the environment from the potential hazards associated with skatole.

Check Digit Verification of cas no

The CAS Registry Mumber 19501-89-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,5,0 and 1 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 19501-89:
(7*1)+(6*9)+(5*5)+(4*0)+(3*1)+(2*8)+(1*9)=114
114 % 10 = 4
So 19501-89-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO/c1-7-5-4-6-8-9(7)12-10(13)11(8,2)3/h4-6H,1-3H3,(H,12,13)

19501-89-4Relevant academic research and scientific papers

Friedel-Crafts chemistry. Part 40. An expedient novel synthesis of some dibenz-azepines, -azocines, 11H-benzo[f]pyrido[2,3-b]azepines and 6H-benzo[g]pyrido[2,3-c]azocines

Abd El-Aal, Hassan A.K.,Khalaf, Ali A.

, p. 306 - 322 (2013/10/21)

A new synthetic approach for the synthesis of novel 5H-dibenz[b,f]azepine, 5H-dibenz[b,f]-azocine, 11H-benzo[f]pyrido[2,3-b]azepine and 6H-benzo[g]pyrido[2,3-c]azocine derivatives is reported. The key step of this methodology is based on Friedel-Crafts ring closure of nitrogen containing carboxylic acids and alkanols in the presence of AlCl3, P 2O5 or PPA catalysts in overall high yields. The starting carboxylic acids were prepared via an unequivocal synthetic pathway by the basic hydrolysis of trimethyloxindole followed by N-arylation reactions.

CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS

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Page/Page column 87, (2016/02/02)

There are described cydohexyl amide derivatives useful as corticotropin releasing factor (CRF) receptor antagonists

Synthesis of 1,3-dihydro-3,3-dimethyl-2H-indol-2-one derivatives as possible nonsteroidal cardiotonics

Lee,Huang,Lin,Shih,Lee,Lin

, p. 1 - 11 (2007/10/02)

New substituted 1,3-dihydro-3,3-dimethyl-2H-indol-2-one derivatives 19-29 and 34-43 were synthesized and examined for their inotropic activity in isolated dog ventricular tissues. Among them, compound 26 (2-(2,3-dimethoxybenzylamino)-N-(3,3,7-trimethyl-2-oxo-2,3-dihydro-1H-i ndol-5-yl)acetamide) showed very potent activity.

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