23423-38-3Relevant academic research and scientific papers
Friedel-Crafts chemistry. Part 40. An expedient novel synthesis of some dibenz-azepines, -azocines, 11H-benzo[f]pyrido[2,3-b]azepines and 6H-benzo[g]pyrido[2,3-c]azocines
Abd El-Aal, Hassan A.K.,Khalaf, Ali A.
, p. 306 - 322 (2013/10/21)
A new synthetic approach for the synthesis of novel 5H-dibenz[b,f]azepine, 5H-dibenz[b,f]-azocine, 11H-benzo[f]pyrido[2,3-b]azepine and 6H-benzo[g]pyrido[2,3-c]azocine derivatives is reported. The key step of this methodology is based on Friedel-Crafts ring closure of nitrogen containing carboxylic acids and alkanols in the presence of AlCl3, P 2O5 or PPA catalysts in overall high yields. The starting carboxylic acids were prepared via an unequivocal synthetic pathway by the basic hydrolysis of trimethyloxindole followed by N-arylation reactions.
