19504-94-0Relevant academic research and scientific papers
Antiproliferative and structure activity relationships of amaryllidaceae alkaloids
Cedrón, Juan C.,Ravelo, ángel G.,León, Leticia G.,Padrón, José M.,Estévez-Braun, Ana
, p. 13854 - 13863 (2015)
The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived
COMPOUNDS AND COMPOSITIONS FOR INHIBITION AND ELIMINATION OF ZIKA INFECTION AND USES FOR SAME
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Paragraph 0094; 0095, (2018/10/19)
Provided are compounds and compositions for prevention and/or elimination of Zika virus infection. Also provided are methods for preventing and treating a subject in need of prevention or treatment of Zika virus.
Total synthesis of (±)-8-Oxo-erythrinine, (±)-8-oxo-erythraline, and (±)-clivonine
He, Maomao,Qu, Chunrong,Ding, Bingbing,Chen, Hao,Li, Yangyan,Qiu, Guofu,Hu, Xianming,Hong, Xuechuan
, p. 3240 - 3250 (2015/05/20)
Total syntheses of the erythrina alkaloids (±)-8-oxo-erythrinine and (±)-8-oxo-erythraline have been developed, based on a substrate-controlled intramolecular 6-exo-trig selective radical spirocyclization that establishes the quaternary center of the B-ri
Preparation and antimalarial activity of semisynthetic lycorenine derivatives
Cedrón, Juan C.,Gutiérrez, David,Flores, Ninoska,Ravelo, ángel G.,Estévez-Braun, Ana
, p. 722 - 730 (2013/07/27)
A set of twenty one lycorenine derivatives has been prepared from the alkaloid hippeastrine (1). The modifications performed on hippeastrine included some functional group transformations, structural simplification and preparation of dimers. All alkaloids were tested as potential antimalarial agents, being the hippeastrine dimers the most active compounds.
Total synthesis of the Amaryllidaceae alkaloid clivonine
Haning, Helmut,Giro-Manas, Carles,Paddock, Victoria L.,Bochet, Christian G.,White, Andrew J. P.,Bernardinelli, Gerald,Mann, Inderjit,Oppolzer, Wolfang,Spivey, Alan C.
, p. 2809 - 2820 (2011/05/12)
Two syntheses of the Amaryllidaceae alkaloid clivonine (1) are described. Both employ previously reported 7-arylhydrindane 6 as an intermediate but differ in the method employed for subsequent introduction of what becomes the ring-B lactone carbonyl carbon (C7). The synthesis featuring a Bischler-Napieralski reaction for this transformation constitutes the first asymmetric synthesis of natural (+)-clivonine. Crystal structures for compounds (±)-13, (±)-16, (-)-20 and (±)-28 are also reported.
Total synthesis of the lycorenine-type amaryllidaceae alkaloid (±)-Clivonine via a biomimetic ring-switch from a lycorine-type progenitor
Giro Mannas, Carles,Paddock, Victoria L.,Bochet, Christian G.,Spivey, Alan C.,White, Andrew J. P.,Mann, Inderjit,Oppolzer, Wolfgang
supporting information; experimental part, p. 5176 - 5178 (2010/06/18)
A fully diastereoselective total synthesis of the lycorenine-type Amaryllidaceae alkaloid (±)-clivonine (19) is reported via a route that employs for the first time a biomimetic ring-switch from a lycorine-type progenitor, thereby corroborating experimentally the biogenetic hypothesis first expounded for these compounds by Barton in 1960.
SYNTHESIS OF AN AMARYLLIDACEAE ALKALOID, (+/-)-HIPPEASTRINE
Katakawa, Jun'ichi,Merugi, Haruo,Irie, Hiroshi
, p. 2213 - 2216 (2007/10/02)
Total synthesis of one of Amaryllidaceae alkaloids, hippeastrine, was accomplished starting from methyl 2c-(N-methoxycarbonylamino)-3t-(3,4-methylenedioxyphenyl)cyclohex-4-enyl-r-acetate in stereoselective manner.
