195056-66-7Relevant articles and documents
New asymmetric synthesis of dexecadotril and ecadotril starting from a single precursor
Monteil,Danvy,Plaquevent,Duhamel,Duhamel,Gros,Schwartz,Lecomte
, p. 211 - 218 (2007/10/03)
We describe herein a method providing access to both enantiomers of 3-acetylthio-2-benzylpropionic acid via enzymatic desymmetrization of 2-benzyl-1,3-propanediol. These compounds are respectively the starting materials for the synthesis of ecadotril, and dexecadotril, which are powerful inhibitors of NEP (EC 3.4.24.11) and have been developed as therapeutic agents.
An efficient enantioselective preparation of 2-substituted-3-hydroxypropionic acids via chemo-enzymatic reaction
Atsuumi, Shugo,Nakano, Masato,Koike, Yutaka,Tanaka, Seiichi,Ohkubo, Mitsuru,Yonezawa, Toshiko,Funabashi, Hiroshi,Hashimoto, Junko,Morishima, Hajime
, p. 1601 - 1604 (2007/10/02)
The key intermediates, 2-substituted-3-hydroxypropionic acids 1, of the potent renin inhibitors were synthesized enantioselectively starting from 2-substituted-1,3-propanediols via chemo-enzymatic reaction.
