195059-44-0

Basic information

• Product Name: (2R,3S)-N²-benzyl-3-(tert-butoxycarbonylamino)-2-(hydroxyamino)butane
• CAS NO: 195059-44-0
• Molecular Weight: 294.394
• Mol File: 195059-44-0.mol

Chemical Properties

• CAS DataBase Reference: (2R,3S)-N²-benzyl-3-(tert-butoxycarbonylamino)-2-(hydroxyamino)butane(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-N²-benzyl-3-(tert-butoxycarbonylamino)-2-(hydroxyamino)butane(195059-44-0)
• EPA Substance Registry System: (2R,3S)-N²-benzyl-3-(tert-butoxycarbonylamino)-2-(hydroxyamino)butane(195059-44-0)

Safety Data

• Hazardous Substances Data: 195059-44-0(Hazardous Substances Data)

Upstream product

• 75-16-1 methylmagnesium bromide 
• 162740-15-0 (Z)-N-<(2S)-2-(tert-butoxycarbonylamino)propylidene> benzylamine N-oxide 

Relevant articles and documents

Stereoselective Grignard reactions to α-amino nitrones. Synthesis of optically active α-aminohydroxylamines and 1,2-diamines

α-Aminohydroxylamines are formed stereoselectively from the nucleophilic addition of phenylmagnesium bromide to α-amino nitrones. In contrast, the addition of methylmagnesium bromide occurs in a stereorandom fashion. Nevertheless it is possible to achieve a complete syn selectivity by diprotecting the α-amino group in the starting nitrone. Hydrogenation of the obtained α-amino hydroxylamines followed by deprotection of the tert-butoxycarbonyl group affords optically active 1,2-diamines.