195156-13-9Relevant academic research and scientific papers
Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model
Sasaki, Kazue,Minowa, Nobuto,Kuzuhara, Hiroyuki,Nishiyama, Shoji
, p. 4900 - 4911 (2007/10/03)
To shed light on the structure-activity relationship, various soyasapogenol B derivatives were synthesized and evaluated for preventive effects on liver injury in the concanavalin A (Con A)-induced hepatitis model in mice. Con A injection into mice induces some pathophysiology of human liver disease such as autoimmune or viral hepatitis. Two hydroxyl groups on the A ring of soyasapogenol B are required for amelioration of liver damage. Modification of the C-22 hydroxyl moiety with an acyloxy or alkyloxy group, or removal of the hydroxyl group, resulted in a greatly enhanced percentage of alleviation. Among the series of soyasapogenol B derivatives examined, six compounds exhibited preventive effects on liver damage.
