195191-47-0

Basic information

• Product Name: 2-Bromo-4-chloro-6-fluoroaniline
• Synonyms: 6-BroMo-4-chloro-2-fluoroaniline;2-BROMO-4-CHLORO-6-FLUOROANILINE;2-AMINO-1-BROMO-5-CHLORO-3-FLUOROBENZENE;2-Bromo-4-chloro-6-fluoroaniline 98%;2-Bromo-4-chloro-6-fluoroaniline98%;2-Fluoro-4-Chloro-6-Bromo aniline;2-BROMO-4-CHLORO-6-FLUOROANILINE, 97+%
• CAS NO: 195191-47-0
• Molecular Formula: C6H4BrClFN
• Molecular Weight: 224.46
• Product Categories: Fluorine series;Anilines, Aromatic Amines and Nitro Compounds;Anilines, Amides & Amines;Bromine Compounds;Chlorine Compounds;Fluorine Compounds;Amines;C2 to C6;Nitrogen Compounds
• Mol File: 195191-47-0.mol

Chemical Properties

• Melting Point: 41-43 °C(lit.)
• Boiling Point: 243°Cat760mmHg
• Flash Point: >230 °F
• Appearance: pink to brown solid
• Density: 1.809g/cm³
• Vapor Pressure: 0.033mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Room temperature.
• Solubility: soluble in Methanol
• PKA: 0.51±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-4-chloro-6-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-chloro-6-fluoroaniline(195191-47-0)
• EPA Substance Registry System: 2-Bromo-4-chloro-6-fluoroaniline(195191-47-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-37/39-36/37/39-24/25
• WGK Germany: 3
• Hazardous Substances Data: 195191-47-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-4-chloro-6-fluoroaniline is used as a chemical intermediate for the preparation of fragment A of an orally bioavailable and CNS penetrant bradykinin1 antagonist. This application is significant because it targets the development of drugs that can effectively cross the blood-brain barrier and provide relief for conditions related to the central nervous system.
The unique structural features of 2-Bromo-4-chloro-6-fluoroaniline, including the presence of multiple halogens, make it a valuable compound for further chemical modifications and the synthesis of more complex molecules with potential therapeutic properties. Its use in the pharmaceutical industry highlights the importance of understanding the chemical properties and reactivity of such compounds in drug discovery and development processes.

InChI:InChI=1/C6H4BrClFN/c7-4-1-3(8)2-5(9)6(4)10/h1-2H,10H2

Downstream Products

• 1448440-22-9 6-chloro-8-fluoro-2-(phenylamino)-4H-benzo[d][1,3]oxazin-4-one 
• 937054-31-4 methyl 2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate 
• 937054-32-5 methyl 2-[(4S,6R)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6h-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate 
• 937054-36-9 Ethyl 2-(1-{2-[(4S,6R)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetate 
• 937054-35-8 Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetate 
• 937054-37-0 2-(1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid 
• 937054-38-1 ethyl 2-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetate 
• 937054-47-2 Ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-3-yl)acetate 
• 937054-46-1 ethyl 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-5-yl)acetate 
• 937054-42-7 2-(2-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)acetic acid 
• 937054-48-3 2-(1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,4-triazol-3-yl)acetic acid 
• 937054-51-8 1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-carboxylic acid 
• 937054-52-9 1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazole-4-carboxylic acid 
• 937054-43-8 3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid