937054-51-8

Basic information

• Product Name: 1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-carboxylic acid
• Synonyms: 1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-carboxylic acid
• CAS NO: 937054-51-8
• Molecular Weight: 512.925
• Mol File: 937054-51-8.mol

Chemical Properties

• CAS DataBase Reference: 1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-carboxylic acid(937054-51-8)
• EPA Substance Registry System: 1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-carboxylic acid(937054-51-8)

Safety Data

• Hazardous Substances Data: 937054-51-8(Hazardous Substances Data)

Upstream product

• 195191-47-0 2-bromo-4-chloro-6-fluorobenzenamine 
• 937057-66-4 2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl methanesulfonate 
• 937054-31-4 methyl 2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate 
• 937057-68-6 (4R,6S)-4-(2-Azidoethyl)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine 
• 937057-63-1 methyl (E)-3-{1-[4-chloro-2-(2,3-dimethoxybenzoyl)-6-fluorophenyl]-1H-pyrrol-2-yl}-acrylate 
• 937054-30-3 Methyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate 
• 937057-60-8 (5-chloro-3-fluoro-2-pyrrol-1-ylphenyl)-(2,3-dimethoxyphenyl)methanol 
• 937057-61-9 (5-chloro-3-fluoro-2-pyrrol-1-ylphenyl)-(2,3-dimethoxyphenyl)methanone 
• 937057-59-5 1-(2-Bromo-4-chloro-6-fluorophenyl)-1H-pyrrole 
• 937054-49-4 1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-carboxylic acid ethyl ester 

Relevant articles and documents

TRICYCLIC COMPOUND

The present invention relates to tricyclic compounds each represented by the following formula (I): (wherein, R1, R2, R2', R3, R4, X, Y and Z have the same meanings as defined in the specification); and a drug containing the compound. Since the compounds according to the present invention exhibit an excellent squalene synthetase inhibitory effect and cholesterol synthesis inhibitory effect so that they are useful as a drug such as preventive and/or remedy for diseases in mammals including humans such as hyperlipemia, e.g., hypercholesterolemia, hypertriglyceridemia, and low HDL cholesterolemia and/or arteriosclerosis.