1952-38-1Relevant articles and documents
Structural and ethylene oligomerization studies of chelated N?O (imino/amino)phenol nickel(II) complexes
Ngcobo, Makhosonke,Ojwach, Stephen O.
, p. 33 - 39 (2017)
Condensation reactions of 2-aminoethanol with the appropriate aldehyde gave ligands 2-[1-[(2-hydroxyethyl)imino]ethyl]phenol (L1) and 2-[(2-hydroxyethyl)imino] methyl]phenol (L2) respectively. Subsequent reductions of L1 and L2 with NaBH4 affor
Heterometallic CoIII4FeIII2 schiff base complex: Structure, electron paramagnetic resonance, and alkane oxidation catalytic activity
Nesterov, Dmytro S.,Pombeiro, Armando J. L.,Chygorin, Eduard N.,Kokozay, Volodymyr N.,Bon, Volodymyr V.,Boca, Roman,Kozlov, Yuriy N.,Shul'Pin, Georgiy B.,Shul'Pina, Lidia S.,Jezierska, Julia,Ozarowski, Andrew
, p. 9110 - 9122,13 (2012)
The heterometallic complex [Co4Fe2OSae 8]·4DMF·H2O (1) was synthesized by one-pot reaction of cobalt powder with iron chloride in a dimethylformamide solution of salicylidene-2-ethanolamine (H2Sae) and characterized by single crystal X-ray diffraction analysis, magnetic measurements, high frequency electron paramagnetic resonance (HF-EPR), and Moessbauer spectroscopies. The exchange coupling in the Fe(III)-Fe(III) pair is of antiferromagnetic behavior with J/hc = -190 cm-1. The HF-EPR spectra reveal an unusual pattern with a hardly detectable triplet signal of the Fe(III) dimer. The magnitude of D (ca. 13.9 cm-1) was found to be much larger than in related dimers. The catalytic investigations disclosed an outstanding activity of 1 toward oxidation of cycloalkanes with hydrogen peroxide, under mild conditions. The most efficient system showed a turnover number (TON) of 3.57×10 3 with the concomitant overall yield of 26% for cyclohexane, and 2.28×103/46%, respectively, for cyclooctane. A remarkable turnover frequency (TOF) of 1.12×104 h-1 (the highest initial rate W0 = 3.5×10-4 M s-1) was achieved in oxidation of cyclohexane. Kinetic experiments and selectivity parameters led to the conclusion that hydroxyl radicals are active (attacking C-H bonds) species. Kinetic and electrospray ionization mass spectrometry (ESI-MS) data allowed us to assume that the trinuclear heterometallic particle [Co2Fe(Sae)4]+, originated from 1 in solution, could be responsible for efficient generation of hydroxyl radicals from hydrogen peroxide.
Details make the difference: A family of tetranuclear CuIIMnIII complexes with cube-like and double open cube-like cores
Stetsiuk, Oleh,Nesterova, Oksana V.,Kokozay, Vladimir N.,Domasevitch, Kostiantyn V.,Omelchenko, Iryna V.,Shishkin, Oleg V.,Vranovi?ová, Beata,Bo?a, Roman,Pombeiro, Armando J. L.,Petrusenko, Svitlana R.
, p. 7480 - 7494 (2017)
The "direct synthesis" approach, namely one-pot reaction of metal powders and ammonium salt with a methanol solution of a polydentate Schiff base (H2L) formed in situ from salicylaldehyde and ethanolamine, has been successfully used for the pre
An oxorhenium(V) Schiff-base complex: Synthesis, structure, spectroscopic characterization, electrochemistry, and DFT calculations
Majumder, Smita,Naskar, Jnan Prakash,Banerjee, Snehasis,Bhattacharya, Arnab,Mitra, Partha,Chowdhury, Shubhamoy
, p. 1178 - 1188 (2013)
Reaction of the Schiff base 2-[(2-hydroxyethylimino)methyl]phenol (H 2L) with trans-ReOCL3(PPh3)2 in 1 : 1M ratio in dichloromethane gives [ReOCL2(HL)(PPh3)] (1) in substantial yield. The compound has been chara
Discovery of clinical candidate (1 R,4 r)-4-((R)-2-((S)-6-Fluoro-5 H-imidazo[5,1-A[isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a potent and selective inhibitor of indoleamine 2,3-dioxygenase 1
Kumar, Sanjeev,Waldo, Jesse P.,Jaipuri, Firoz A.,Marcinowicz, Agnieszka,Van Allen, Clarissa,Adams, James,Kesharwani, Tanay,Zhang, Xiaoxia,Metz, Richard,Oh, Angela J.,Harris, Seth F.,Mautino, Mario R.
, p. 6705 - 6733 (2019/08/20)
A novel class of 5-substituted 5H-imidazo[5,1-a]isoindoles are described as potent inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1). A structure-based drug design approach was used to elaborate the 5H-imidazo[5,1-a]isoindole core and to improve potency and pharmacological properties. Suitably placed hydrophobic and polar functional groups in the lead molecule allowed improvement of IDO1 inhibitory activity while minimizing off-target liabilities. Structure-activity relationship studies focused on optimizing IDO1 inhibition potency and a pharmacokinetic profile amenable to oral dosing while controlling CYP450 and hERG inhibitory properties.