195210-68-5

Basic information

• Product Name: Carbamic acid, diethyl-, 2-(phenylmethyl)phenyl ester
• CAS NO: 195210-68-5
• Molecular Formula: C18H21NO2
• Molecular Weight: 283.37
• Mol File: 195210-68-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, diethyl-, 2-(phenylmethyl)phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, diethyl-, 2-(phenylmethyl)phenyl ester(195210-68-5)
• EPA Substance Registry System: Carbamic acid, diethyl-, 2-(phenylmethyl)phenyl ester(195210-68-5)

Safety Data

• Hazardous Substances Data: 195210-68-5(Hazardous Substances Data)

Upstream product

• 28994-41-4 o-Benzylphenol 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 65009-00-9 O-phenyl N,N-diethylcarbamate 
• 100-39-0 benzyl bromide 

Downstream Products

• 606-97-3 2-benzyl-1,1'-biphenyl 
• 3117-37-1 3-phenyl-3H-benzofuran-2-one 
• 195210-78-7 N,N-Diethyl-2-(2-hydroxy-phenyl)-2-phenyl-acetamide 

Relevant articles and documents

N,N-diethyl O-carbamate: Directed metalation group and orthogonal Suzuki-Miyaura cross-coupling partner

(Chemical Equation Presented) The first Suzuki-Miyaura cross-coupling of an aryl O-carbamate, a versatile and powerful directed metalation group (DMG) in directed ortho metalation (DoM) chemistry, is described using the inexpensive, bench-stable catalyst NiCl2(PCy3)2. Broad synthetic scope and good efficiency are demonstrated for aryl and heteroaryl O-carbamates. The role of water and hydrolysis equilibrium between free boronic acid and boroxine was established to be a crucial parameter for this transformation. When combined with DoM and traditional Pd-catalyzed Suzuki-Miyaura strategies, the methodology offers concise routes to uniquely substituted molecules, avoiding the need for protection/deprotection of the phenol and the use of strongly nucleophilic cross-coupling partners.