19525-53-2Relevant articles and documents
Bromelain catalyzed synthesis of peptides in organic solvent
Tai, Dar-Fu,Fu, Shu-Lin
, p. 179 - 183 (2007/10/03)
For the first time, immobilized bromelain was shown to maintain high catalytic activity in organic solvent and to form peptide bonds. It requires only 7 hours to obtain Cbz-Gly-L-Leu-OMe in 85% yield. The precursor of aspartame (Cbz-L-Asp-L-Phe-OMe) and other dipeptides were also synthesized by this method.
STUDIES ON AMINO ACIDS AND PEPTIDES-III. 2,4-BIS(4-METHOXYPHENYL)-1,3,2,4-DITHIADIPHOSPHETANE 2,4-DISULFIDE, LR, AS A NEW RACEMIZATION FREE COUPLING REAGENT IN PEPTIDE SYNTHESIS
Pedersen, U.,Thorsen, M.,El-Khrisy, E. -E. A. M.,Clausen, K.,Lawesson, S. -O.
, p. 3267 - 3269 (2007/10/02)
The easily accesable 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide, LR, has been reacted with salts of N-protected amino acids 1 (Z-Gly-OH, Boc-Gly-OH, Boc-S-Ser(Bzl)-OH, Bos-S-Tyr(Bzl)-OH, Z-S-Arg(Z2)-OH, and Z-S-Pro-OH), at room tem
