195259-54-2Relevant academic research and scientific papers
An acyliminium ion approach towards the synthesis of β-substituted 3,4-dihydroisoquinolone propionates
Fisher, Matthew J.,Gunn, Bruce P.,Um, Suzane,Jakubowski, Joseph A.
, p. 5747 - 5750 (2007/10/03)
A variety of α-methoxy amides were prepared either by selective reduction of the exocyclic carbonyl of a 2-acyl-3,4-dihydroisoquinolone and subsequent trapping of the resultant α-hydroxy amide with acidic methanol or by reacting the sodium salt of 3,4-dihydroisoquinolone with a functionalized α-chloro ether. These intermediates were reacted with 1-tert-butoxy-1-tert-butyldimethylsiloxy ethene in the presence of BF3·Et2O providing access to β-substituted isoquinolone propionates in good yield.
