195304-70-2

Upstream product

• 123334-78-1 2'-azido-2',3'-dideoxy-3'-fluoroadenosine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 195304-72-4 Benzoic acid (2R,3R,4R,5R)-4-{[(2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethoxy]-[2-(4-nitro-phenyl)-ethoxy]-phosphoryloxy}-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

Synthesis and biological activity of modified (2'-5')triadenylates containing 2'-terminal 2',3'-dideoxy-3'-fluoroadenosine derivatives

Some new (2'-5')triadenylates 13-16, containing at the 2'-terminal end 3'-fluoro-2',3'-dideoxyadenosine derivatives, have been synthesized by the phosphotriester method. The selectively blocked nucleosides 2, 4, 5, and 7 were synthesized from the corresponding unprotected 'nucleosides 1, 3, and 6. The synthesized trimers 13 and 14 were 4- and 8-fold, respectively, more stable towards phosphodiesterase from Crotalus durissus than the natural trimer 17. In comparison to trimer 17 the new compounds 13-15 inhibit HIV-1 reverse transcriptase (RT) activity, and 15 and 16 the HIV-1 induced syncytia formation 2-3 fold whereas none of 13-16 can improve RNase L activity.