195316-40-6

Basic information

• Product Name: 2,2-Dimethyl-propionic acid (4S,5S)-5-[(2R,3R,4R,5R)-3-hydroxy-4-methoxymethoxy-5-(2-trityloxy-ethyl)-tetrahydro-furan-2-yl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
• Synonyms: 2,2-Dimethyl-propionic acid (4S,5S)-5-[(2R,3R,4R,5R)-3-hydroxy-4-methoxymethoxy-5-(2-trityloxy-ethyl)-tetrahydro-furan-2-yl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
• CAS NO: 195316-40-6
• Molecular Weight: 648.794
• Mol File: 195316-40-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2-Dimethyl-propionic acid (4S,5S)-5-[(2R,3R,4R,5R)-3-hydroxy-4-methoxymethoxy-5-(2-trityloxy-ethyl)-tetrahydro-furan-2-yl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dimethyl-propionic acid (4S,5S)-5-[(2R,3R,4R,5R)-3-hydroxy-4-methoxymethoxy-5-(2-trityloxy-ethyl)-tetrahydro-furan-2-yl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester(195316-40-6)
• EPA Substance Registry System: 2,2-Dimethyl-propionic acid (4S,5S)-5-[(2R,3R,4R,5R)-3-hydroxy-4-methoxymethoxy-5-(2-trityloxy-ethyl)-tetrahydro-furan-2-yl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester(195316-40-6)

Safety Data

• Hazardous Substances Data: 195316-40-6(Hazardous Substances Data)

Upstream product

• 195316-08-6 (2R,3S,4S,5R)-4-Benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-((4S,5S)-2,2-dimethyl-5-trityloxymethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-ol 
• 195316-36-0 (2R,3R,4S,5R)-4-Benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-((4S,5S)-2,2-dimethyl-5-trityloxymethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-ol 
• 195316-32-6 [(2R,3R,4S,5R)-4-Benzyloxy-5-((4S,5S)-2,2-dimethyl-5-trityloxymethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-ylmethoxy]-tert-butyl-diphenyl-silane 
• 195316-31-5 (1S,2S)-1-[(2S,3S,4R,5R)-3-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-3-trityloxy-propane-1,2-diol 
• 195316-33-7 Toluene-4-sulfonic acid (2R,3R,4S,5R)-4-benzyloxy-5-((4S,5S)-2,2-dimethyl-5-trityloxymethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-ylmethyl ester 
• 195316-35-9 {2-[(2R,3R,4S,5R)-4-Benzyloxy-5-((4S,5S)-2,2-dimethyl-5-trityloxymethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-ethoxy}-tert-butyl-dimethyl-silane 
• 195316-37-1 {2-[(2R,3S,4R,5R)-4-Benzyloxy-5-((4S,5S)-2,2-dimethyl-5-trityloxymethyl-[1,3]dioxolan-4-yl)-3-methoxymethoxy-tetrahydro-furan-2-yl]-ethoxy}-tert-butyl-dimethyl-silane 
• 1054633-74-7 (2R,4R,5S)-4-Benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-((4S,5S)-2,2-dimethyl-5-trityloxymethyl-[1,3]dioxolan-4-yl)-dihydro-furan-3-one 
• 195316-06-4 2-[2-(2R,3R,4S,5S)-4-benzyloxy-5-((1S,2S)-1,2-isopropylidenedioxy-3-trityloxypropyl)-3-(4-methoxybenzyloxy)tetrahydrofuranyl]acetonitrile 
• 195316-07-5 (2S,3S,4R,5R)-3-benzyloxy-5-(2-hydroxyethyl)-2-((1S,2S)-1,2-isopropylidenedioxy-3-trityloxypropyl)-4-(4-methoxybenzyloxy)tetrahydrofuran 
• 195315-91-4 (S)-4-{(S)-[(2S,3S,4R,5R)-3-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-hydroxy-methyl}-[1,3]dioxolan-2-one 
• 195316-05-3 (2S,3S,4R,5R)-3-benzyloxy-5-hydroxymethyl-2-((1S,2S)-1,2-isopropylidenedioxy-3-trityloxypropyl)-4-(4-methoxybenzyloxy)tetrahydrofuran 
• 195316-34-8 [(2R,3R,4S,5R)-4-Benzyloxy-5-((4S,5S)-2,2-dimethyl-5-trityloxymethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-acetaldehyde 
• 195315-86-7 (2R,3R,4R,5S)-4-benzyloxy-5-(1,3-dithian-2-yl)-3-(4-methoxybenzyloxy)-2-trityloxymethyltetrahydrofuran 

Downstream Products

• 1053252-49-5 (2R,3S,3aR,4aS,7R,8aS,9S,9aR)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3,9-bis-triethylsilanyloxy-2-(2-trityloxy-ethyl)-decahydro-furo[3,2-b]pyrano[2,3-e]pyran 
• 195316-43-9 Toluene-4-sulfonic acid 2-[(3aS,4S,5aR,6S,7R,8aR,8bR)-6-methoxymethoxy-2,2-dimethyl-7-(2-trityloxy-ethyl)-hexahydro-[1,3]dioxolo[4,5]furo[2,3-b]pyran-4-yl]-ethyl ester 
• 195316-11-1 (E)-3-{(4S,5S)-5-[(2S,3R,4S,5R)-4-Methoxymethoxy-3-triethylsilanyloxy-5-(2-trityloxy-ethyl)-tetrahydro-furan-2-yl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-acrylic acid ethyl ester 
• 195316-45-1 [(2R,3S,3aR,4aS,7R,8aS,9S,9aR)-3,9-Diacetoxy-2-(2-trityloxy-ethyl)-decahydro-furo[3,2-b]pyrano[2,3-e]pyran-7-yl]-acetic acid methyl ester 
• 195316-14-4 (E)-5-[(3aS,4S,5aR,6S,7R,8aR,8bR)-6-Methoxymethoxy-2,2-dimethyl-7-(2-trityloxy-ethyl)-hexahydro-[1,3]dioxolo[4,5]furo[2,3-b]pyran-4-yl]-pent-2-enoic acid methyl ester 
• 1053727-15-3 (4R,5R)-5-[(2S,3R,4S,5R)-4-Methoxymethoxy-3-triethylsilanyloxy-5-(2-trityloxy-ethyl)-tetrahydro-furan-2-yl]-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 195316-12-2 [(3aS,4S,5aR,6S,7R,8aR,8bR)-6-Methoxymethoxy-2,2-dimethyl-7-(2-trityloxy-ethyl)-hexahydro-[1,3]dioxolo[4,5]furo[2,3-b]pyran-4-yl]-acetic acid ethyl ester 
• 195316-10-0 {(4S,5S)-5-[(2S,3R,4S,5R)-4-Methoxymethoxy-3-triethylsilanyloxy-5-(2-trityloxy-ethyl)-tetrahydro-furan-2-yl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol 
• 195316-17-7 (2R,3S,3aS,4aS,7R,8aR,9S,9aS)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(2-trityloxy-ethyl)-decahydro-furo[3,2-b]pyrano[2,3-e]pyran-3,9-diol 
• 195316-15-5 [(2R,3S,3aS,4aS,7R,8aR,9S,9aS)-3,9-Dihydroxy-2-(2-trityloxy-ethyl)-decahydro-furo[3,2-b]pyrano[2,3-e]pyran-7-yl]-acetic acid methyl ester 
• 195316-44-0 3-[(3aS,4S,5aR,6S,7R,8aR,8bR)-6-Methoxymethoxy-2,2-dimethyl-7-(2-trityloxy-ethyl)-hexahydro-[1,3]dioxolo[4,5]furo[2,3-b]pyran-4-yl]-propionaldehyde 
• 195316-13-3 3-[(3aS,4S,5aR,6S,7R,8aR,8bR)-6-Methoxymethoxy-2,2-dimethyl-7-(2-trityloxy-ethyl)-hexahydro-[1,3]dioxolo[4,5]furo[2,3-b]pyran-4-yl]-propionitrile 
• 195316-42-8 2-[(3aS,4S,5aR,6S,7R,8aR,8bR)-6-Methoxymethoxy-2,2-dimethyl-7-(2-trityloxy-ethyl)-hexahydro-[1,3]dioxolo[4,5]furo[2,3-b]pyran-4-yl]-ethanol 
• 195316-47-3 (2R,3S,3aS,4aS,7R,8aR,9S,9aS)-7-(2-Hydroxy-ethyl)-2-(2-trityloxy-ethyl)-decahydro-furo[3,2-b]pyrano[2,3-e]pyran-3,9-diol 

Relevant articles and documents

Synthetic studies of halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. 6. Synthesis of the C1 - C15 unit via stereoselective construction of the B and A rings by kinetically and thermodynamically controlled Michael reactions with the aid of computational search for dominant conformers

The C1 - C15 unit of halichondrin B was synthesized starting from D- glucose via stereoselective construction of the B and A rings, which have 2,6-trans- and 2,6-cis-disubstituted tetrahydropyran rings, respectively. With the aid of MM2 calculations kinetically and thermodynamically controlled Michael reactions were successfully applied for the construction of the B and A rings, respectively.