195316-06-4

Upstream product

• 22529-61-9 (1R)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro(2,3-d)(1,3)dioxol-5-yl)ethane-1,2-diol 
• 155369-79-2 (2R,3R,4S,5R)-4-Benzyloxy-5-[1,3]dithian-2-yl-2-hydroxymethyl-tetrahydro-furan-3-ol 
• 195315-85-6 (2R,3R,4S,5R)-4-benzyloxy-5-(1,3-dithian-2-yl)-3-hydroxy-2-trityloxymethyltetrahydrofuran 
• 195316-23-5 (E)-3-[(2S,3R,4R,5R)-3-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-prop-2-en-1-ol 
• 155369-81-6 {(2R,3S)-3-[(2R,3S,4R,5R)-3-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-oxiranyl}-methanol 
• 195316-32-6 [(2R,3R,4S,5R)-4-Benzyloxy-5-((4S,5S)-2,2-dimethyl-5-trityloxymethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-ylmethoxy]-tert-butyl-diphenyl-silane 
• 195316-31-5 (1S,2S)-1-[(2S,3S,4R,5R)-3-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-3-trityloxy-propane-1,2-diol 
• 195315-91-4 (S)-4-{(S)-[(2S,3S,4R,5R)-3-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-hydroxy-methyl}-[1,3]dioxolan-2-one 
• 195316-05-3 (2S,3S,4R,5R)-3-benzyloxy-5-hydroxymethyl-2-((1S,2S)-1,2-isopropylidenedioxy-3-trityloxypropyl)-4-(4-methoxybenzyloxy)tetrahydrofuran 
• 195315-86-7 (2R,3R,4R,5S)-4-benzyloxy-5-(1,3-dithian-2-yl)-3-(4-methoxybenzyloxy)-2-trityloxymethyltetrahydrofuran 
• 155369-82-7 (1S,2S)-1-[(2S,3S,4R,5R)-3-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-propane-1,2,3-triol 
• 155369-80-5 (E)-3-[(2S,3R,4R,5R)-3-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-acrylic acid ethyl ester 
• 195315-90-3 [(2R,3R,4S,5R)-4-Benzyloxy-5-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-ylmethoxy]-tert-butyl-diphenyl-silane 
• 195316-22-4 [(2R,3R,4S,5R)-4-Benzyloxy-5-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-methanol 

Downstream Products

• 195316-34-8 [(2R,3R,4S,5R)-4-Benzyloxy-5-((4S,5S)-2,2-dimethyl-5-trityloxymethyl-[1,3]dioxolan-4-yl)-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-acetaldehyde 
• 195316-47-3 (2R,3S,3aS,4aS,7R,8aR,9S,9aS)-7-(2-Hydroxy-ethyl)-2-(2-trityloxy-ethyl)-decahydro-furo[3,2-b]pyrano[2,3-e]pyran-3,9-diol 
• 195316-42-8 2-[(3aS,4S,5aR,6S,7R,8aR,8bR)-6-Methoxymethoxy-2,2-dimethyl-7-(2-trityloxy-ethyl)-hexahydro-[1,3]dioxolo[4,5]furo[2,3-b]pyran-4-yl]-ethanol 
• 195316-13-3 3-[(3aS,4S,5aR,6S,7R,8aR,8bR)-6-Methoxymethoxy-2,2-dimethyl-7-(2-trityloxy-ethyl)-hexahydro-[1,3]dioxolo[4,5]furo[2,3-b]pyran-4-yl]-propionitrile 
• 195316-44-0 3-[(3aS,4S,5aR,6S,7R,8aR,8bR)-6-Methoxymethoxy-2,2-dimethyl-7-(2-trityloxy-ethyl)-hexahydro-[1,3]dioxolo[4,5]furo[2,3-b]pyran-4-yl]-propionaldehyde 
• 195316-15-5 [(2R,3S,3aS,4aS,7R,8aR,9S,9aS)-3,9-Dihydroxy-2-(2-trityloxy-ethyl)-decahydro-furo[3,2-b]pyrano[2,3-e]pyran-7-yl]-acetic acid methyl ester 
• 195316-17-7 (2R,3S,3aS,4aS,7R,8aR,9S,9aS)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(2-trityloxy-ethyl)-decahydro-furo[3,2-b]pyrano[2,3-e]pyran-3,9-diol 
• 195316-10-0 {(4S,5S)-5-[(2S,3R,4S,5R)-4-Methoxymethoxy-3-triethylsilanyloxy-5-(2-trityloxy-ethyl)-tetrahydro-furan-2-yl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol 
• 195316-40-6 2,2-Dimethyl-propionic acid (4S,5S)-5-[(2R,3R,4R,5R)-3-hydroxy-4-methoxymethoxy-5-(2-trityloxy-ethyl)-tetrahydro-furan-2-yl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester 
• 195316-12-2 [(3aS,4S,5aR,6S,7R,8aR,8bR)-6-Methoxymethoxy-2,2-dimethyl-7-(2-trityloxy-ethyl)-hexahydro-[1,3]dioxolo[4,5]furo[2,3-b]pyran-4-yl]-acetic acid ethyl ester 
• 1053727-15-3 (4R,5R)-5-[(2S,3R,4S,5R)-4-Methoxymethoxy-3-triethylsilanyloxy-5-(2-trityloxy-ethyl)-tetrahydro-furan-2-yl]-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 195316-14-4 (E)-5-[(3aS,4S,5aR,6S,7R,8aR,8bR)-6-Methoxymethoxy-2,2-dimethyl-7-(2-trityloxy-ethyl)-hexahydro-[1,3]dioxolo[4,5]furo[2,3-b]pyran-4-yl]-pent-2-enoic acid methyl ester 
• 195316-41-7 2,2-Dimethyl-propionic acid (4S,5S)-5-[(2S,3R,4S,5R)-4-methoxymethoxy-3-triethylsilanyloxy-5-(2-trityloxy-ethyl)-tetrahydro-furan-2-yl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester 
• 195316-45-1 [(2R,3S,3aR,4aS,7R,8aS,9S,9aR)-3,9-Diacetoxy-2-(2-trityloxy-ethyl)-decahydro-furo[3,2-b]pyrano[2,3-e]pyran-7-yl]-acetic acid methyl ester 

Relevant academic research and scientific papers

Synthetic studies of halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. 6. Synthesis of the C1 - C15 unit via stereoselective construction of the B and A rings by kinetically and thermodynamically controlled Michael reactions with the aid of computational search for dominant conformers

The C1 - C15 unit of halichondrin B was synthesized starting from D- glucose via stereoselective construction of the B and A rings, which have 2,6-trans- and 2,6-cis-disubstituted tetrahydropyran rings, respectively. With the aid of MM2 calculations kinetically and thermodynamically controlled Michael reactions were successfully applied for the construction of the B and A rings, respectively.