195318-34-4Relevant academic research and scientific papers
Visible-light-driven selective alkenyl C-P bond cleavage of allenylphosphine oxides
Wei, Kai,Luo, Kai,Liu, Fang,Wu, Lei,Wu, Li-Zhu
, p. 1994 - 1998 (2019/03/29)
An efficient method for highly selective alkenyl C-P bond cleavage, enabled by organic dyes and visible-light irradiation, was developed. This novel protocol involves a highly regioselective radical pathway initiated by singlet oxygen, affording diverse a
Efficient synthesis of 4-halo-2,5-dihydro-1,2-oxaphosphole 2-oxides from 1,2-allenylphosphonates and CuX2 and subsequent suzuki cross-coupling of the C-Cl bonds
Xin, Ning,Ma, Shengming
experimental part, p. 3806 - 3817 (2012/09/22)
A convenient and efficient synthesis of 4-halo-2,5-dihydro-1,2-oxaphosphole 2-oxides through CuX2-mediated direct halocyclization of diethyl 1,2-allenylphosphonates was developed. The yields range from moderate to excellent. The efficiency of axial-to-central chirality transfer has also been studied. Further Suzuki cross-coupling of the resulting vinylic chlorides with dicyclohexyl(2,4,6-trimethoxyphenyl)phosphane (LB-Phos) as the ligand, was established. CuX2-mediated direct halocyclization of diethyl 1,2-allenylphosphonates was developed to afford 4-halo-2,5-dihydro-1,2- oxaphosphole 2-oxides. The efficiency of axial-to-central chirality transfer and subsequent Suzuki cross-coupling of the resultingvinylic chlorides with dicyclohexyl(2,4,6-trimethoxyphenyl)phosphane (LB-Phos) as the ligand were also investigated. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
