19533-08-5

Upstream product

• 49645-89-8 o-Hydroxyacetophenone sodium salt 
• 106-89-8 epichlorohydrin 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 83047-60-3 1-{2-[3-(2-Acetyl-phenoxy)-2-hydroxy-propylamino]-ethyl}-3-phenyl-urea 
• 147849-87-4 2'-(3-tert-Butylamino-2-hydroxypropoxy)acetophenone 
• 25684-28-0 6-methyl-3,4-dihydro-2H-benzo[b][1,5]oxazocin-3-ol 
• 132948-75-5 1-<2-<2-hydroxy-3-(4-morpholinyl)propoxy>phenyl>-1-ethanone 
• 27799-71-9 6-(4-nitro-styryl)-3,4-dihydro-2H-benzo[b][1,5]oxazocin-3-ol 
• 27799-70-8 6-styryl-3,4-dihydro-2H-benzo[b][1,5]oxazocin-3-ol 
• 25684-30-4 DL-3,4-Dihydro-3-hydroxy-6-methyl-8-nitro-1,5-benzoxazocin 
• 147849-84-1 6-<2-(3-tert-Butyl-2-oxo-5-oxazolidinylmethoxy)phenyl>-4,5-dihydro-4-hydroxy-3(2H)-pyridazinone 
• 147849-88-5 2'-<2-Acetoxy-3-propoxy>acetophenone 
• 98441-41-9 6-<2-(3-tert-Butylamino-2-hydroxypropoxy)phenyl>-3(2H)-pyridazinone 
• 147849-89-6 5-(2-Acetylphenoxymethyl)-3-tert-butyloxazolidin-2-one 
• 118468-12-5 1-[2-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-ethanone 
• 143328-69-2 1-{2-[(S)-3-(2-Benzoyl-4-chloro-phenylamino)-2-hydroxy-propoxy]-phenyl}-ethanone 
• 143328-77-2 1-{2-[(R)-3-(2-Benzoyl-4-chloro-phenylamino)-2-hydroxy-propoxy]-phenyl}-ethanone 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of novel desloratadine derivatives with anti-inflammatory and H1 antagonize activities

To improve the anti-inflammatory activity of desloratadine, we designed and synthesized a series of novel desloratadine derivatives. All compounds were evaluated for their anti-inflammatory and H1 antagonistic activities. Among them, compound 2c showed the strongest H1 antagonistic and anti-inflammatory activity. It also exhibited promising pharmacokinetic profiles and low toxicity. All these results suggest that compound 2c as a novel anti-allergic agent is worthy of further investigation.

Synthesis and In Vitro Pharmacological Evaluation of 5-(Alkoxymethyl)-2-(3-alkylamino-2-hydroxypropoxy)phenylethanones Related to Acebutolol and Celiprolol

The structure–activity relationships of 13 analogs of aryloxyaminopropanol type derived from 2-hydroxyphenylethanone as potential β-blockers are described. The synthesized compounds possess an isopropyl or a tert-butyl group in the hydrophilic part of the

The hERG potassium channel and drug trapping: Insight from docking studies with propafenone derivatives

The inner cavity of the hERG potassium ion channel can accommodate large, structurally diverse compounds that can be trapped in the channel by closure of the activation gate. A small set of propafenone derivatives was synthesized, and both use-dependency and recovery from block were tested in order to gain insight into the behavior of these compounds with respect to trapping and non-trapping. Ligand-protein docking into homology models of the closed and open state of the hERG channel provides the first evidence for the molecular basis of drug trapping.

Synthesis, Pharmacologic Activity, and Structure-Activity Relationships of a Series of Propafenone-Related Modulators of Multidrug Resistance

A series of propanolamines have been prepared and evaluated for multidrug resistance-reverting activity in a human tumor cell model.Structure-activity relationship studies indicate that the phenylpropiophenone moiety as well as the substitution pattern at the nitrogen atom is crucial for activity of the compounds.Incorporation of the ether oxygen into a benzofuran substructure, which renders the compound an arylethanolamine, decreased biologic activity.Highest activity could be observed with the arylpiparazines 4f-h, which not only completely restored daunomycin sensitivity but also showed moderate activity in restoring etoposide toxicity.

Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry

Novel compounds of the general formula STR1 and the pharmaceutically acceptable esters and acid addition salts thereof, wherein: R1, R2, R3, R4 and R5 are each independently hydrogen, lower alkyl, lower alkoxy, cyano, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, N-optionally substituted alkylamido, except that when R1 is methyl, R4 is not methyl; or R2 and R3 together form --OCH2 O--; R6, R7, R8, R9 and R10 are each independently hydrogen, lower acyl, aminocarbonylmethyl, cyano, lower alkyl, lower alkoxy, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, di-lower alkyl amino; or R6 and R7 together form --CH=CH--CH=CH--; R7 and R8 together form --OCH2 O--; R11 and R12 are each independently hydrogen or lower alkyl; and W is oxygen or sulfur. These cardioselective compounds have calcium entry blockade properties and therefore are useful in therapy in the treatment of cardiovascular diseases, including arrhythmias, variant and exercise induced angina and myocardial infarction.