195375-40-7

Upstream product

• 76-83-5 trityl chloride 
• 182747-96-2 5'-O-(4-methoxybenzoyl)-3'-amino-3'-deoxythymidine 
• 134077-32-0 3'-Azido-5'-O-(4-methoxybenzoyl)-3'-deoxythymidine 

Downstream Products

• 195375-68-9 3'-NH-trityl-3'-aminothymidine 5'-O-cyanoethyl-N,N-diisopropylaminophosphoramidite 
• 195375-41-8 1-[(2R,4S,5S)-5-Hydroxymethyl-4-(trityl-amino)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

N3′→P5′ Oligodeoxyribonucleotide Phosphoramidates: A New Method of Synthesis Based on a Phosphoramidite Amine-Exchange Reaction

A new method for the synthesis of N3′→P5′ phosphoramidate oligodeoxynucleotides is demonstrated. Described herein is the synthesis of the monomers utilized in the phosphoramidite amine-exchange process and the experimental details pertaining to this new mode of chain assembly. The phosphoramidite amine-exchange method generates coupling yields in the 92-95% range per cycle and further enables the synthesis of chimeric phosphoramidate/phosphodiester or phosphoramidate/ phosphorothioate oligonucleotides with no instrument modifications.