195375-57-6

Upstream product

• 195375-56-5 Diphenyl-carbamic acid 9-[(2R,4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-(trityl-amino)-tetrahydro-furan-2-yl]-2-isobutyrylamino-9H-purin-6-yl ester 
• 195375-51-0 N₂-isobutyryl-5'-O-tert-butyldimethylsilyl-2'-deoxyxyloguanosine 
• 195375-53-2 N-{9-[(2R,4S,5S)-4-Amino-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide 
• 195375-54-3 5'-O-(tert-butyldimethylsilyl)-N²-isobutyryl-3'-tritylamino-2',3'-dideoxyguanosine 
• 195375-52-1 3'-azido-5'-O-tert-butyldimethylsilyl-N₂-isobutyryl-2',3'-dideoxyguanosine 
• 121513-00-6 [(2R,3R,5R)-2-(hydroxymethyl)-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]tetrahydrofuran-3-yl] benzoate 
• 76-83-5 trityl chloride 

Relevant academic research and scientific papers

N3′→P5′ Oligodeoxyribonucleotide Phosphoramidates: A New Method of Synthesis Based on a Phosphoramidite Amine-Exchange Reaction

A new method for the synthesis of N3′→P5′ phosphoramidate oligodeoxynucleotides is demonstrated. Described herein is the synthesis of the monomers utilized in the phosphoramidite amine-exchange process and the experimental details pertaining to this new mode of chain assembly. The phosphoramidite amine-exchange method generates coupling yields in the 92-95% range per cycle and further enables the synthesis of chimeric phosphoramidate/phosphodiester or phosphoramidate/ phosphorothioate oligonucleotides with no instrument modifications.