1954-58-1

Upstream product

• 67-56-1 methanol 
• 2491-06-7 N,N-dimethylglycine hydrochoride 
• 1118-68-9 dimethylaminoacetic acid 

Downstream Products

• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 65753-93-7 N-methyl-2-dimethylamino-acetohydroxamic acid 

Relevant academic research and scientific papers

Syntheses of 1,2-di-O -palmitoyl-sn -glycero-3-phosphocholine (DPPC) and analogs with 13C- and 2H-labeled choline head groups

The syntheses of four head group labeled analogs of 1,2-di-O-palmitoyl-sn-glycero-3-phosphoc (DPPC) (6) by a general method from 1,2-di-O-palmitoyl-sn -glycero-3-phosphatidic acid (5) have been performed. The syntheses of 1,2-di-O-palmitoyl-sn-glycero-3-phospho[α-13C]choline (6a) and 1,2-di-O-palmitoyl-sn-glycero-3-phospho[β13C]choline (6b) were performed from labeled [l-13C]glycine (1a) in 52% overall yield and from [2-13C]glycine (1b) in 56% overall yield, respectively. 1,2-Di-O-palmitoyl-sn-glycero-3-phosphol[N(C2H3)3]choline (9) was prepared from 2-aminoethanol in 39% overall yield. 1,2-Di- O-palmitoyl-sn-glycero-3-phospho[α-C2H2]choline (12) was prepared from N,N-dimethylglycine ethyl ester in 50% overall yield.

N-METHYL-2-DIMETHYLAMINOACETOHYDROXAMIC ACID AS A NEW REAGENT FOR THE SELECTICE CLEVEAGE OF ACTIVE ESTERS UNDER NEUTRAL CONDITIONS

A new reagent, N-methyl-2-dimethylaminoacetohydroxamic acid 3 was developed for the selective cleavage of active esters under neutral conditions.The kinetic studies and the applications of 3 are described.