195451-17-3

Upstream product

• 159884-54-5 1-(2,2-diethoxyethyl)-1H-indole-2,3-dione 3-(O-methyloxime) 
• 622-58-2 p-Tolylisocyanate 
• 91-56-5 indole-2,3-dione 
• 107976-78-3 1H-indole-2,3-dione 3-(O-methyloxime) 
• 159884-41-0 1-(2,2-diethoxyethyl)indoline-2,3-dione 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 

Downstream Products

• 159883-92-8 [(R)-1-(2,2-diethoxyethyl)-2-oxo-3-(3-p-tolylureido)-2,3-dihydro-1H-indol-3-yl]acetic acid (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ester 
• 159882-93-6 (+)-1-(2,2-diethoxyethyl)-3-((4-methylphenyl)-aminocarbonylmethyl)-3-(N'-(4-methylphenyl)ureido)indolin-2-one 
• 199800-49-2 AG 041R 
• 913191-67-0 [(R)-2-oxo-1-(2-oxo-ethyl)-3-(3-p-tolylureido)-2,3-dihydro-1H-indol-3-yl]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 159884-50-1 [1-(2,2-diethoxy-ethyl)-2-oxo-3-(3-p-tolyl-ureido)-2,3-dihydro-1H-indol-3-yl]-acetic acid 

Relevant academic research and scientific papers

Phosphine-catalyzed (3+2)/(2+3) sequential annulation involving a triple nucleophilic addition reaction of γ-vinyl allenoates

A phosphine-catalyzed (3+2)/(2+3) sequential annulation involving a triple nucleophilic addition reaction of γ-vinyl allenoates was successfully developed. The reaction provided efficient and more practical access to functionalized hydropyrroloimidazolone

Efficient asymmetric synthesis of novel gastrin receptor antagonist AG-041R via highly stereoselective alkylation of oxindole enolates

An efficient method for asymmetric synthesis of the potent Gastrin/CCK-B receptor antagonist AG-041R was developed. Core oxindole stereochemistry was established by asymmetric alkylation of oxindole enolates with bromoacetic acid esters, using l-menthol a