195454-06-9

Upstream product

• 195454-05-8 3-(4-{[(4-Hydroxymethyl-phenyl)-dimethyl-silanyl]-methoxy}-phenyl)-propionic acid methyl ester 
• 873-75-6 4-bromobenzenemethanol 
• 181717-64-6 4-(triisopropylsilyloxymethyl)bromobenzene 
• 195454-03-6 1-(Bromomethyl-dimethyl-silanyl)-4-triisopropylsilanyloxymethyl-benzene 
• 195454-04-7 3-(4-{[Dimethyl-(4-triisopropylsilanyloxymethyl-phenyl)-silanyl]-methoxy}-phenyl)-propionic acid methyl ester 

Downstream Products

• 195454-07-0 3-(4-{[(4-{[2-(4-Hydroxy-phenyl)-ethylamino]-methyl}-phenyl)-dimethyl-silanyl]-methoxy}-phenyl)-propionic acid methyl ester 
• 195454-08-1 3-[4-({[4-({Acetyl-[2-(4-hydroxy-phenyl)-ethyl]-amino}-methyl)-phenyl]-dimethyl-silanyl}-methoxy)-phenyl]-propionic acid methyl ester 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 

Relevant academic research and scientific papers

Simple Silyl Linker for the Solid Phase Organic Synthesis of Aryl-Containing Molecules

We have designed a simple (dimethylsilyl)propionic acid linker for the solid phase synthesis of aryl-containing organic compounds. The linker is cleaved smoothly with trifluoroacetic acid either in solution or in the vapor phase to release the unsubstituted aryl moiety. Using this linker, we have successfully demonstrated the solid phase synthesis of a test compound which involved alkylation, acylation, and Mitsunobu reactions.