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195514-80-8

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Basic information
1. Product Name: AP20187
2. Synonyms: AP20187
3. CAS NO:195514-80-8
4. Molecular Formula: C₈₂H₁₀₇N₅O₂₀
5. Molecular Weight: 1482.74848
6. EINECS: N/A
7. Product Categories: N/A
8. Mol File: 195514-80-8.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: N/A
3. Flash Point: N/A
4. Appearance: /
5. Density: N/A
6. Refractive Index: N/A
7. Storage Temp.: N/A
8. Solubility: ≥74.14 mg/mL in DMSO; ≥100 mg/mL in EtOH
9. CAS DataBase Reference: AP20187(CAS DataBase Reference)
10. NIST Chemistry Reference: AP20187(195514-80-8)
11. EPA Substance Registry System: AP20187(195514-80-8)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 195514-80-8(Hazardous Substances Data)

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195514-80-8 Usage

Biological Activity

ap20187 is a small dimerizer drug [1].to solve the graft-versus-host disease, the in vivo behavior of the transplanted cells should be controlled. ap20187 is used in the conditional system as a chemical inducer of dimerization (cid). another component is a fusion protein. the cids have advantages in gene therapy, it offers the possibility of achieving selection without the toxic effects. in vivo studies show that ap20187 can produces a notable expansion of transduced red cells, platelets, and to a lesser extent, granulocytes [1].ap20187 is also reported to be used in an ap20187–lfv2ire system. in this system, ap20187 administration causes the activation of lfv2ire and results in increased uptake of both hepatic glycogen content and muscular glucose [2].

references

[1] neff t, blau ca. pharmacologically regulated cell therapy. blood. 2001 may 1;97(9):2535-40.[2] cotugno g, formisano p, giacco f, colella p, beguinot f, auricchio a. ap20187-mediated activation of a chimeric insulin receptor results in insulin-like actions in skeletal muscle and liver of diabetic mice. hum gene ther. 2007 feb;18(2):106-17.

Check Digit Verification of cas no

The CAS Registry Mumber 195514-80-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,5,5,1 and 4 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 195514-80:
(8*1)+(7*9)+(6*5)+(5*5)+(4*1)+(3*4)+(2*8)+(1*0)=158
158 % 10 = 8
So 195514-80-8 is a valid CAS Registry Number.