19552-53-5

Usage

Molecular weight

96.13 g/mol

Type of compound

aliphatic amine

Derivative of

imidazole

Common uses

building block in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals

Physical properties

clear, colorless, flammable liquid with a faint ammonia-like odor

Known for

versatile chemical structure

Widely used in

pharmaceutical and agrochemical industries

Downstream Products

• 1366126-38-6 C₂₁H₂₃F₃N₄O₂ 
• 1366126-84-2 C₁₇H₁₅ClF₃N₃O 

Relevant academic research and scientific papers

A Simple and Practical Synthesis of 2-Aminoimidazoles

A new and simple two-step procedure to synthesize 2-aminoimidazoles (2-AI's) from readily available materials has been developed.The cyclization reaction of α-halo ketones and N-acetylguanidine in acetonitrile (MeCN) at reflux, or in dimethylformamide (DMF) at ambient temperature, gives 4(5)-substituted and 4,5-disubstituted N-(1H-imidazol-2-yl)acetamides, which are then hydrolyzed to their respective 2-AI's.In general, the purified products were isolated in good yields.We have prepared several examples and have demonstrated the usefulness of this method by its application in the total synthesis of 8, an interesting histamine analog, and oroidin, 15, a marine natural product isolated from various sponges.

Method for inhibiting advanced glycosylation of proteins using aminosubstituted imidazoles

The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging), Accordingly, a composition is disclosed which comprises 2-aminoimidazoles capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation, The method comprises contacting the target protein with the composition, Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.