924-99-2

Basic information

• Product Name: Ethyl 3-(N,N-dimethylamino)acrylate
• Synonyms: DMAE;ETHYL 3-(DIMETHYLAMINO)ACRYLATE;ETHYL 3,3-DIMETHYLAMINOACRYLATE;3-(DIMETHYLAMINO)ACRYLIC ACID ETHYL ESTER;3-DAASE;RARECHEM AL BI 0671;Ethyl 3-(N,N-dimethylamino)acrylate, 99+%;ethyl 3-(dimethylamino)propenoate
• CAS NO: 924-99-2
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18
• EINECS: 402-650-4
• Product Categories: Acids and Derivatives;Amines and Anilines;Small molecule;API intermediates
• Mol File: 924-99-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 17-18 °C
• Boiling Point: 118-121 °C (7.501 mmHg)
• Flash Point: 105 °C
• Appearance: Clear yellow to light orange/Liquid
• Density: 1
• Vapor Pressure: 0.683mmHg at 25°C
• Refractive Index: 1.5105-1.5125
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.67±0.70(Predicted)
• Water Solubility: 90 g/L (25 ºC)
• CAS DataBase Reference: Ethyl 3-(N,N-dimethylamino)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 3-(N,N-dimethylamino)acrylate(924-99-2)
• EPA Substance Registry System: Ethyl 3-(N,N-dimethylamino)acrylate(924-99-2)

Safety Data

• Hazard Codes: Xi
• Statements: 43-36/37/38
• Safety Statements: 37-24-36/37-26
• Hazardous Substances Data: 924-99-2(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow to light orange liquid

Uses

Ethyl 3-(dimethylamino)acrylate is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

InChI:InChI=1/C7H13NO2/c1-4-10-7(9)5-6-8(2)3/h5-6H,4H2,1-3H3/b6-5+

Upstream product

• 124-40-3 dimethyl amine 
• 506-59-2 N,N-dimethylammonium chloride 
• 64-18-6 formic acid 
• 141-78-6 ethyl acetate 
• 201230-82-2 carbon monoxide 
• 20120-21-2 ethyl 3-(N,N-dimethylamino)propionate 
• 127-19-5 N,N-dimethyl acetamide 
• 20353-93-9 Gold's reagent 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 5815-08-7 tert-Butoxybis(dimethylamino)methane 
• 74119-34-9 3-Dimethylamino-2-(formylaminomethyl)acrylsaeure-ethylester 
• 4071-88-9 trimethylsilanyl-acetic acid ethyl ester 
• 34433-91-5 N-formyl-β-alanine ethyl ester 

Downstream Products

• 148926-94-7 ethyl ester of 3-dimethylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid 
• 258345-86-7 ethyl 2-(2,4-dichloro-3-fluoro-5-nitrobenzoyl)-3-(dimethylamino)acrylate 
• 258345-84-5 ethyl 2-(2,4-dichloro-3-ethyl-5-nitrobenzoyl)-3-(dimethylamino)acrylate 
• 127625-17-6 ethyl ester of 1-cyclopropyl-6-nitro-4-oxo-7-chloro-1,4-dihydroquinoline-3-carboxylic acid 
• 161040-78-4 6-Amino-1-tert-butyl-4-oxo-7-pyrrolidin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 148926-95-8 ethyl ester of 3-cyclopropylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid 
• 161040-76-2 6-Amino-1-tert-butyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 161040-31-9 (Z)-3-tert-Butylamino-2-(2,4-dichloro-5-nitro-benzoyl)-acrylic acid ethyl ester 
• 148927-35-9 ethyl 1-(4-fluorophenyl)-7-chloro-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylate 
• 162558-46-5 6-Amino-1-(4-fluoro-phenyl)-4-oxo-7-thiomorpholin-4-yl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 161040-32-0 (Z)-2-(2,4-Dichloro-5-nitro-benzoyl)-3-(4-fluoro-phenylamino)-acrylic acid ethyl ester 
• 161040-82-0 6-Amino-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 161040-65-9 1-(4-Fluoro-phenyl)-6-nitro-4-oxo-7-thiomorpholin-4-yl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 161040-64-8 1-(4-Fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 

Relevant articles and documents

Preparation method of ethyl 3-(N,N-dimethylamino)acrylate

The invention relates to a preparation method of ethyl 3-(N,N-dimethylamino)acrylate, which comprises the following steps: carrying out heating reaction on formic acid, ethyl acetate and dimethylamineto obtain ethyl 3-(N,N-dimethylamino)acrylate and water. The preparation method of the ethyl 3-(N,N-dimethylamino)acrylate is short in reaction route, high in yield and purity and low in safety risk.

Ethyl N,N-dimethylaminoacrylate synthesis method

The invention relates to the technical field of synthesis of fine chemical intermediates, particularly to an ethyl N,N-dimethylaminoacrylate synthesis method, which comprises that ethyl acetate, carbon monoxide and dimethylamine are used as starting raw materials, and are subjected to a reaction under the action of a solid alkali catalyst to form the target product ethyl N,N-dimethylaminoacrylate,wherein the solid alkali catalyst is preferably a supported solid alkali catalyst. According to the present invention, the problems that the raw material source is difficult, the price is expensive,the process condition is harsh, the three-waste amount is high, the yield is low, the cost is high, the method is not suitable for industrial production and the like in the prior art are solved; and the synthesis method of the present invention has characteristics of convenient raw material source, low cost, environmentally-friendly reaction condition, substantially-reduced side-product, high total yield, high raw material utilization rate, low production cost and high product purity, and is suitable for large-scale industrial continuous production.

Synthesis method for N,N-dimethylaminoethyl acrylate

The invention discloses a synthesis method for N,N-dimethylaminoethyl acrylate. The method includes the following steps that 1, raw material preparation is carried out, wherein ethyl acetate, carbon monoxide, dimethylamine carbonate and sodium ethoxide serve as raw material; 2, material blending is carried out, wherein the molar ratio of ethyl acetate to carbon monoxide to dimethylamine carbonate to sodium ethoxide is (3-4):(0.9-1.1):(1.0-1.30):(1.2-1.4); 3, ethyl acetate, dimethylamine carbonate and sodium ethoxide are added into a vessel, carbon monoxide is introduced into the vessel, the temperature in the kettle is controlled to be 45-50 DEG C at the pressure of 0.2-0.8 MPa, and a heat-preserved reaction is carried out for 10 h; 4, after the reaction is finished, reduced pressure distillation is carried out to distill off a solvent, and the distilled solvent is recycled; 5, water is added into the vessel, standing is carried out for layering, an oil phase enters a rectification system, and N,N-dimethylaminoethyl acrylate is obtained through rectification. The product synthesized with the method contains few impurities, the amount of wastewater is small, the water resource is saved, the yield is high and reaches 5%, and the content is increased to 99.5% or above from 98%.