195534-11-3Relevant academic research and scientific papers
Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues
Fei, Xiangshu,Zheng, Qi-Huang,Wang, Ji-Quan,Stone, K. Lee,Martinez, Tanya D.,Miller, Kathy D.,Sledge, George W.,Hutchins, Gary D.
, p. 1247 - 1251 (2004)
Radiolabeled antimitotic agents [11C]T138067 and [ 18F]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of [
Hydrophilic, pro-drug analogues of T138067 are efficacious in controlling tumor growth in vivo and show a decreased ability to cross the blood brain barrier
Rubenstein,Baichwal,Beckmann,Clark,Frankmoelle,Roche,Santha,Schwender,Thoolen,Ye,Jaen
, p. 3599 - 3605 (2007/10/03)
The novel anticancer compound T138067 is an irreversible inhibitor of tubulin polymerization. Amides 3-6 were synthesized using standard methodologies and determined to be significantly less lipophilic than T138067 based on logP calculations. Tubulin poly
Arylsulfonanilide ureas
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, (2008/06/13)
The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states,
Arylsulfonanilide derivatives
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, (2008/06/13)
The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states,
