308338-41-2Relevant academic research and scientific papers
Hydrophilic, pro-drug analogues of T138067 are efficacious in controlling tumor growth in vivo and show a decreased ability to cross the blood brain barrier
Rubenstein,Baichwal,Beckmann,Clark,Frankmoelle,Roche,Santha,Schwender,Thoolen,Ye,Jaen
, p. 3599 - 3605 (2007/10/03)
The novel anticancer compound T138067 is an irreversible inhibitor of tubulin polymerization. Amides 3-6 were synthesized using standard methodologies and determined to be significantly less lipophilic than T138067 based on logP calculations. Tubulin poly
