195624-84-1 Usage
Description
2-Iodo-1-methoxy-4-(trifluoromethyl)benzene is an organic compound characterized by its unique molecular structure, which features an iodine atom at the 2nd position, a methoxy group at the 1st position, and a trifluoromethyl group at the 4th position on a benzene ring. 2-iodo-1-methoxy-4-(trifluoromethyl)benzene is known for its potential applications in various chemical and pharmaceutical processes due to its distinct functional groups and reactivity.
Uses
Used in Pharmaceutical Industry:
2-Iodo-1-methoxy-4-(trifluoromethyl)benzene is used as a reagent for the preparation of chiral hydropyrimidines, which are important in the pharmaceutical industry. These chiral compounds are often key components in the development of new drugs, particularly those targeting specific biological receptors or enzymes. The unique structure of 2-iodo-1-methoxy-4-(trifluoromethyl)benzene allows for the synthesis of chiral hydropyrimidines with desired stereochemistry, enhancing the effectiveness and selectivity of the resulting pharmaceuticals.
Additionally, due to its reactivity and functional groups, 2-iodo-1-methoxy-4-(trifluoromethyl)benzene may also find applications in other areas of the chemical industry, such as in the synthesis of various organic compounds, materials, or intermediates for further chemical transformations.
Check Digit Verification of cas no
The CAS Registry Mumber 195624-84-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,5,6,2 and 4 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 195624-84:
(8*1)+(7*9)+(6*5)+(5*6)+(4*2)+(3*4)+(2*8)+(1*4)=171
171 % 10 = 1
So 195624-84-1 is a valid CAS Registry Number.
195624-84-1Relevant articles and documents
Transition-Metal-Free Decarboxylative Iodination: New Routes for Decarboxylative Oxidative Cross-Couplings
Perry, Gregory J. P.,Quibell, Jacob M.,Panigrahi, Adyasha,Larrosa, Igor
supporting information, p. 11527 - 11536 (2017/08/30)
Constructing products of high synthetic value from inexpensive and abundant starting materials is of great importance. Aryl iodides are essential building blocks for the synthesis of functional molecules, and efficient methods for their synthesis from chemical feedstocks are highly sought after. Here we report a low-cost decarboxylative iodination that occurs simply from readily available benzoic acids and I2. The reaction is scalable and the scope and robustness of the reaction is thoroughly examined. Mechanistic studies suggest that this reaction does not proceed via a radical mechanism, which is in contrast to classical Hunsdiecker-type decarboxylative halogenations. In addition, DFT studies allow comparisons to be made between our procedure and current transition-metal-catalyzed decarboxylations. The utility of this procedure is demonstrated in its application to oxidative cross-couplings of aromatics via decarboxylative/C-H or double decarboxylative activations that use I2 as the terminal oxidant. This strategy allows the preparation of biaryls previously inaccessible via decarboxylative methods and holds other advantages over existing decarboxylative oxidative couplings, as stoichiometric transition metals are avoided.
