19575-04-3

Upstream product

• 98-01-1 furfural 
• 350-03-8 methyl-3-pyridylketone 

Downstream Products

• 64388-71-2 2-furan-2-yl-1-phenyl-4-pyridin-3-yl-butane-1,4-dione 
• 1649454-90-9 4-(2-furyl)-6-[(2-oxo-2-phenylethyl)thio]-2,3'-bipyridine-5-carbonitrile 
• 1649454-98-7 [3-amino-4-(2-furyl)-6-(pyridin-3-yl)thieno[2,3-b]pyridin-2-yl](phenyl)methanone 
• 1649454-99-8 [3-amino-4-(2-furyl)-6-(pyridin-3-yl)thieno[2,3-b]pyridin-2-yl](4-chlorophenyl)methanone 
• 1358067-70-5 4-(2-furyl)-6-thioxo-1,6-dihydro-2,3'-bipyridine-5-carbonitrile 

Relevant academic research and scientific papers

1-Acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles: Exhibiting anticancer activity through intracellular ROS scavenging and the mitochondria-dependent death pathway

A series of 17 analogs of 1-acetyl-4,5-dihydro(1H)pyrazoles (JP-1 to JP-17) bearing two aromatic rings at positions 3 and 5, either of which ought to be heterocyclic, were synthesized and evaluated for their anti-proliferative potential against breast cancer (MCF-7 and T-47D) and lung cancer (H-460 and A-549) cell lines for the first time. JP-1-7, -10, -11, -14, and -15 were observed to exhibit significant anti-proliferative activity against MCF-7 cells. Some notions about structure-activity relationships are reported. The investigated compounds were found to lower the intracellular reactive oxygen species in the H2DCFDA assay and also caused mitochondria-dependent cell death in the MCF-7 cell line, indicating a plausible mechanism of their anticancer effect. Analogs of 1-acetyl-4,5-dihydro(1H)pyrazoles (JP-1-17) were synthesized and evaluated for their anti-proliferative activity in four cancer cell lines and for their intracellular ROS scavenging properties. An attempt was made to determine the mitochondrial membrane potential of MCF-7 cells treated with JP-1 and -14, aiming to elucidate the mechanism by which proliferation was curbed.

NOVEL PROPENONE DERIVATIVES CONTAINING AROMATIC RINGS, A MAUFACTURING PROCESS THEREOF AND A COMPOSITION CONTAINING THE SAME USING AS AN ANTIINFLAMMATORY AGENT

The present invention is related to novel propenone derivatives containing aromatic ring, a manufacturing process thereof and a composition containing the same using as an anti? inflammatory agent. The compound of the present invention show potent anti-inflammatory activity confirmed by various experiments for example, the inhibition test of COX and 5-LOX enzyme activity, the inhibition test of LTC reproduction and NO production, MTT assay test, the inhibition test on the iNOS and COX-2 protein expression and PGE reproduction using RAW 264.7 macrophage etc. Accordingly, present compounds can be useful in treating and preventing various inflammatory.