19575-04-3

Basic information

• Product Name: 3-(furan-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one
• CAS NO: 19575-04-3
• Molecular Formula: C₁₂H₉NO₂
• Molecular Weight: 199.2054
• Mol File: 19575-04-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 342.9°C at 760 mmHg
• Flash Point: 161.2°C
• Density: 1.201g/cm³
• Vapor Pressure: 7.31E-05mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: 3-(furan-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(furan-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one(19575-04-3)
• EPA Substance Registry System: 3-(furan-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one(19575-04-3)

Safety Data

• Hazardous Substances Data: 19575-04-3(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 350-03-8 methyl-3-pyridylketone 

Downstream Products

• 1358067-70-5 4-(2-furyl)-6-thioxo-1,6-dihydro-2,3'-bipyridine-5-carbonitrile 
• 1649454-99-8 [3-amino-4-(2-furyl)-6-(pyridin-3-yl)thieno[2,3-b]pyridin-2-yl](4-chlorophenyl)methanone 
• 1649454-98-7 [3-amino-4-(2-furyl)-6-(pyridin-3-yl)thieno[2,3-b]pyridin-2-yl](phenyl)methanone 
• 1649454-90-9 4-(2-furyl)-6-[(2-oxo-2-phenylethyl)thio]-2,3'-bipyridine-5-carbonitrile 
• 64388-71-2 2-furan-2-yl-1-phenyl-4-pyridin-3-yl-butane-1,4-dione 

Relevant articles and documents

1-Acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles: Exhibiting anticancer activity through intracellular ROS scavenging and the mitochondria-dependent death pathway

A series of 17 analogs of 1-acetyl-4,5-dihydro(1H)pyrazoles (JP-1 to JP-17) bearing two aromatic rings at positions 3 and 5, either of which ought to be heterocyclic, were synthesized and evaluated for their anti-proliferative potential against breast cancer (MCF-7 and T-47D) and lung cancer (H-460 and A-549) cell lines for the first time. JP-1-7, -10, -11, -14, and -15 were observed to exhibit significant anti-proliferative activity against MCF-7 cells. Some notions about structure-activity relationships are reported. The investigated compounds were found to lower the intracellular reactive oxygen species in the H2DCFDA assay and also caused mitochondria-dependent cell death in the MCF-7 cell line, indicating a plausible mechanism of their anticancer effect. Analogs of 1-acetyl-4,5-dihydro(1H)pyrazoles (JP-1-17) were synthesized and evaluated for their anti-proliferative activity in four cancer cell lines and for their intracellular ROS scavenging properties. An attempt was made to determine the mitochondrial membrane potential of MCF-7 cells treated with JP-1 and -14, aiming to elucidate the mechanism by which proliferation was curbed.

CONDENSATIONS OF NICOTINOYLACETIC ACID ETHYL ESTER WITH ALDEHYDES. I.

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