19578-84-8Relevant academic research and scientific papers
Multiple arylation of phenols around the oxygen under palladium catalysis
Kawamura, Yoshiki,Satoh, Tetsuya,Miura, Masahiro,Nomura, Masakatsu
, p. 961 - 962 (1999)
Phenols undergo pentaarylation around the oxygen upon a single treatment with excess aryl bromides in the presence of a palladium catalyst system to produce 2-(1,1′-biphenyl-2-yl)-6-(1,1′:3′,1″-terphenyl-2′- yl)phenol derivatives.
Metal-Free C-O Bond Functionalization: Catalytic Intramolecular and Intermolecular Benzylation of Arenes
Bering, Luis,Jeyakumar, Kirujan,Antonchick, Andrey P.
supporting information, p. 3911 - 3914 (2018/07/22)
A catalytic, metal-free intramolecular rearrangement of benzyl phenyl ethers using nitrosonium salt as a catalyst is described. The optimized reaction conditions enabled a catalytic and metal-free Friedel-Crafts alkylation reaction with benzylic alcohols, producing water as the stoichiometric byproduct. A comprehensive scope (>50 examples) for both approaches and application in drug synthesis were demonstrated. Mechanistic studies suggest a Lewis acid-based mechanism for the metal-free Friedel-Crafts reaction.
