195834-11-8

Upstream product

• 127301-68-2 C₇H₈O₃S*C₇H₁₂N₂O₂ 
• 501-53-1 benzyl chloroformate 
• 52486-67-6 benzyloxycarbonylamino-cyano-acetic acid 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 1046783-92-9 (R)-1-benzyl 2-tert-butyl 2-cyano-4-iodo-5-oxo-1H-pyrrole-1,2(2H,5H)-dicarboxylate 
• 1010807-63-2 t-butyl 2-benzyloxycarbonylamino-2-cyano-3-[(-)-menthyloxycarbonyl]propionate 

Relevant academic research and scientific papers

SUCCINIC ACID DIESTER DERIVATIVE, PROCESS FOR PRODUCTION THEREOF, AND USE OF THE DERIVATIVE IN THE PRODUCTION OF PHARMACEUTICAL PREPARATION

The present invention provides with a process of preparing an optically active succinimide derivative, which is a key intermediate for production of ranirestat. A compound (3) is easily prepared by treating the derivative of succinic acid diester of the formula (2): wherein R1 is an amino group protected with a group removed by hydrogenolysis or a tert-butoxycarbonylamino group and R2 is an ethyl group optionally substituted with one or two methyl group(s) at α-position, provided that R2 is not a tert-butyl group when R1 is a tert-butoxycarbonylamino group; with alkali metal alkoxide and the compound (3) can be an important intermediate for production of ranirestat.

Organocatalytic asymmetric synthesis of versatile γ-lactams

A goodstarting point: Optically pure glactams have been prepared by organocatalytic enantioselective vinylic substitution. The parent lactam structure allows logical and systematic introduction of functionality around the periphery to access new derivativ