195877-76-0

Upstream product

• 676-58-4 methylmagnesium chloride 
• 958648-31-2 N-(2-methyl-2-propenoyl)bornane-10,2-sultam 
• 60886-80-8 (1S)-(-)-camphorsulfonylimine 

Downstream Products

• 138298-52-9 (E)-1-((1S,5S,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(3-methoxy-phenyl)-propenone 
• 138298-51-8 (E)-1-((1S,5S,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(2-methoxy-phenyl)-propenone 
• 109053-73-8 N-[(5R)-10,10-dimethyl-3,3-dioxo-3-thia-4-azatricyclo[5.2.1.0^1,5]dec-4-yl]-(E)-3-phenylpropenoylamide 
• 195877-80-6 N-propionyl-2(S)-bornane-2,10-sultam 
• 138298-53-0 (E)-1-((1S,5S,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(3,4,5-trimethoxy-phenyl)-propenone 

Relevant academic research and scientific papers

Preparation method of optically pure cyclic amino alcohol and salt thereof

The invention relates to the field of chemical pharmacy, particularly to a preparation method of optically pure cyclic amino alcohol and a salt thereof. The method comprises 1) hydrolysis: hydrolyzinga compound (12) to obtain a compound (13), and 2) catalytic hydrogenation: carrying out catalytic hydrogenation on the compound (13) obtained in the hydrolysis step to obtain a compound (1).

Asymmetric Induction at C(β) and C(α) of N-Enoylsultams by Organomagnesium 1,4-Addition/Enolate Trapping

The 1,4-addition of alkylmagnesium chlorides to conjugated N-enoylsultams and subsequent 'enolate trapping' with aq.NH4Cl or MeI/hexamethylphosphoric triamide generated centers of asymmetry at C(β) and/or at C(α) with good to excellent ?-face differentation as demonstrated by the conversions 1->2, 1->4, and 8->9.This holds also for the regioselective 1,4-addition of EtMgCl to a dienosultam (15->16).Reactive conformations 1, 8, 13, and 14 are postulated in agreement with X-ray evidence which also served for the structure determination of the product 9j.