195884-25-4Relevant academic research and scientific papers
Cyanoacetamides (IV): Versatile one-pot route to 2-quinoline-3-carboxamides
Wang, Kan,Herdtweck, Eberhardt,Doemling, Alexander
scheme or table, p. 316 - 322 (2012/06/18)
Cyanoacetic acid derivatives are the starting materials for a plethora of multicomponent reaction (MCR) scaffolds. Herein, we describe scope of a valuable general protocol for the synthesis of arrays of 2-aminoquinoline-3-carboxamides from cyanoacetamides and 2-aminobenzaldehydes or heterocyclic derivatives via a Friedlaender reaction variation. In many cases, the reactions involve a very convenient work up by simple precipitation and filtration. More than 40 new products are described. We foresee our protocol and the resulting derivatives becoming very valuable to greatly expanding the scaffold space of cyanoacetamide derivatives.
