195967-08-9

Upstream product

• 144944-96-7 3’-O-tert-butyldimethylsilyl-5’-deoxy-5’-mercaptothymidine 
• 195967-07-8 1-[(2R,4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2-nitro-phenyldisulfanylmethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 195967-02-3 Thiobenzoic acid S-[(2S,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 
• 195967-06-7 1-[(2R,4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-benzylsulfanylmethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 199661-18-2 Methanesulfonic acid (2S,3R,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl ester 
• 171563-32-9 5′-O-mesyl-3′-O-tert-butyldimethylsilyl deoxythymidine 
• 146557-80-4 1-{(3'R,4'S)-5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-3'-C-(hydroxymethyl)-β-pentofuranosyl}thymine 
• 40733-27-5 3'-O-(t-butyldimethylsilyl)thymidine 
• 146557-69-9 1-[5-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(formyl)-β-D-erythro-pentofuranosyl]thymine 

Relevant academic research and scientific papers

Dinucleoside monophosphate analogues containing disulfide linkages

The synthesis of two dinucleoside monophosphate analogues is described in which the 3'-O-P-O-5' phosphodiester linkage is replaced by either an isosteric 3'-C-S-S-5' or a shorter 3'-S-S-5' linkage. In both cases the -S-S- bond was formed through a disulfide exchange reaction using an activated S-nucleosidyl S-aryl disulfide and a suitably protected derivative of 5'-thiothymidine.