195967-02-3

Upstream product

• 51066-54-7 sodium thiobenzoate 
• 171563-32-9 5′-O-mesyl-3′-O-tert-butyldimethylsilyl deoxythymidine 
• 98-91-9 thiobenzoic acid 
• 40733-27-5 3'-O-(t-butyldimethylsilyl)thymidine 
• 50-89-5 thymidine 

Downstream Products

• 195967-08-9 C₄₃H₆₀N₄O₈S₂Si₂ 
• 195967-04-5 C₄₇H₅₈N₄O₁₀S₂Si 
• 195967-05-6 C₄₁H₄₄N₄O₁₀S₂ 

Relevant academic research and scientific papers

Dinucleoside monophosphate analogues containing disulfide linkages

The synthesis of two dinucleoside monophosphate analogues is described in which the 3'-O-P-O-5' phosphodiester linkage is replaced by either an isosteric 3'-C-S-S-5' or a shorter 3'-S-S-5' linkage. In both cases the -S-S- bond was formed through a disulfide exchange reaction using an activated S-nucleosidyl S-aryl disulfide and a suitably protected derivative of 5'-thiothymidine.

Dinucleoside monophosphate analogues containing disulfide linkages

Two dinucleoside monophosphate analogues containing disulfide linkages (1 and 2) have been prepared for incorporation into oligonucleotides. The modified oligomers will be tested for their potential as antisense agents.