19598-01-7

Basic information

• Product Name: (1R,2S)-2-CHLORO-INDAN-1-OL
• Synonyms: SPECS AC-082/25006749;1-HYDROXY-2-CHLOROINDANE, CIS ISOMER;(1R,2S)-2-CHLORO-INDAN-1-OL;2-chloroindan-1-ol
• CAS NO: 19598-01-7
• Molecular Formula: C₉H₉ClO
• Molecular Weight: 168.62
• Mol File: 19598-01-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 313.5°Cat760mmHg
• Flash Point: 143.4°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 0.00021mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: (1R,2S)-2-CHLORO-INDAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-2-CHLORO-INDAN-1-OL(19598-01-7)
• EPA Substance Registry System: (1R,2S)-2-CHLORO-INDAN-1-OL(19598-01-7)

Safety Data

• Hazardous Substances Data: 19598-01-7(Hazardous Substances Data)

Usage

General Description

(1R,2S)-2-chloro-indan-1-ol is a chemical compound with the molecular formula C9H9ClO. It is a chiral molecule, meaning it has a non-superimposable mirror image, and it contains a chlorine atom, a hydroxyl group, and a cyclic structure. (1R,2S)-2-CHLORO-INDAN-1-OL is commonly used in the pharmaceutical and chemical industries as a building block for the synthesis of various organic compounds. It possesses potential biological activity and has been studied for its potential applications in medicinal chemistry. Its unique structure and properties make it a valuable tool for researchers and chemists in the development of new drugs and materials.

InChI:InChI=1/C9H9ClO/c10-8-5-6-3-1-2-4-7(6)9(8)11/h1-4,8-9,11H,5H2

Upstream product

• 74925-48-7 1,2-dichloro-2,3-dihydro-1H-indene 
• 95-13-6 1-indene 
• 49716-39-4 ((1S,2S)-2-Chloro-indan-1-yloxymethylene)-dimethyl-ammonium; chloride 
• 123-91-1 1,4-dioxane 
• 7664-93-9 sulfuric acid 
• 19598-01-7 cis-2-chloroindan-1-ol 
• 1579-14-2 2-chloroindanone 

Downstream Products

• 19598-01-7 trans-2-chloroindan-1-ol 
• 4370-02-9 trans-indane-1,2-diol 
• 95-13-6 1-indene 
• 615-13-4 2-indanone 
• 83-33-0 inden-1-one 
• 18427-72-0 2-chloro-1H-indene 
• 74925-48-7 1,2-dichloro-2,3-dihydro-1H-indene 

Relevant articles and documents

Electro-mediated PhotoRedox Catalysis for Selective C(sp3)–O Cleavages of Phosphinated Alcohols to Carbanions

We report a novel example of electro-mediated photoredox catalysis (e-PRC) in the reductive cleavage of C(sp3)?O bonds of phosphinated alcohols to alkyl carbanions. As well as deoxygenations, olefinations are reported which are E-selective and can be made Z-selective in a tandem reduction/photosensitization process where both steps are photoelectrochemically promoted. Spectroscopy, computation, and catalyst structural variations reveal that our new naphthalene monoimide-type catalyst allows for an intimate dispersive precomplexation of its radical anion form with the phosphinate substrate, facilitating a reactivity-determining C(sp3)?O cleavage. Surprisingly and in contrast to previously reported photoexcited radical anion chemistries, our conditions tolerate aryl chlorides/bromides and do not give rise to Birch-type reductions.

Addition of halide to π-bond directly from aqueous NaX solution: A general strategy for installation of two different functional groups

Activation of π-bond with organic Lewis acid and cationic surfactant mediated direct transfer of halides to alkyne and alkene are demonstrated to afford α,α-dihaloketones and other valuable synthons with outstanding selectivities.

Chlorine Dioxide as an Electron-Transfer Oxidant of Olefins

The kinetics and product studies of oxidation of eight olefins 1-8 by ClO2 in H2O in the pH range 3-7 are described.The reaction is faster as the pH decreases.At pH The order of reactivity is: (E)-stilbene > indene > β-methylstyrene > acenaphthylene > α-methylstyrene > styrene > cyclohexene > allylbenzene.A multi-stage radical-cation mechanism is proposed, in which an initial reversible protonation: is followed by an electron-transfer stage (rate-determining): The cation-radical thus produced, adds rapidly an additional ClO2 to from dioxygenated products.The chlorohydrines most likely arise from HClO additions to the olefinic double bonds, which, in turn, generate from dismutation of 2HClO2 into HClO + H+ + ClO3-.