195983-71-2

Upstream product

• 195986-74-4 2,3,4,5-Tetrahydro-7-bromo-1H-1,4-benzodiazepine-2,5-dione 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1026037-59-1 (3,4-dihydro-2H-quinolin-1-yl)-(7-phenyl-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl)-methanone 
• 195986-32-4 N-(4-chlorophenyl)-N'-cyano-1,2,3,5-tetrahydro-7-phenyl-4H-1,4-benzodiazepin-4-imidazmide 
• 195984-22-6 2,3,4,5-Tetrahydro-4-(1-naphthalenylsulfonyl)-7-phenyl-1H-1,4-benzodiazepine 
• 195983-98-3 2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-4-[(1,1-dimethylethoxy)-carbonyl]-7-phenyl-1H-1,4-benzodiazepine 
• 195984-05-5 2,3,4,5-Tetrahydro-4-(1-naphthalenylcarbonyl)-7-phenyl-1H-1,4-benzodiazepine 
• 195985-76-3 2,3,4,5-tetrahydro-7-phenyl-4-(1-phenyl-1H-tetrazol-5-yl)-1H-1,4-benzodiazepine 
• 195983-99-4 2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-7-phenyl-1H-1,4-benzodiazepine 
• 195983-92-7 2,3,4,5-tetrahydro-4-[(1,1-dimethylethoxy)-carbonyl]-7-phenyl-1H-1,4-benzodiazepine 
• 195983-72-3 7-phenyl-1,4-benzodiazepin 

Relevant academic research and scientific papers

Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase

Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formulas their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs and solvates thereof.

Discovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase

2,3,4,5-Tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepines were found to be potent inhibitors of farnesyltransferase (FT). A hydrophobic substituent at the 4-position of the benzodiazepine, linked via a hydrogen bond acceptor, was important to enzyme i