195983-98-3

Upstream product

• 3034-50-2 4⁽⁵⁾formylimidazole 
• 195983-92-7 2,3,4,5-tetrahydro-4-[(1,1-dimethylethoxy)-carbonyl]-7-phenyl-1H-1,4-benzodiazepine 
• 98-80-6 phenylboronic acid 
• 195983-71-2 7-phenyl-1,4-benzodiazepine-2,5-dione 
• 195983-72-3 7-phenyl-1,4-benzodiazepin 
• 195986-74-4 2,3,4,5-Tetrahydro-7-bromo-1H-1,4-benzodiazepine-2,5-dione 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 195983-99-4 2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-7-phenyl-1H-1,4-benzodiazepine 

Relevant academic research and scientific papers

Inhibitors of farnesyl protein transferase

The present invention comprises benzodiazepine compounds having farnesyl transferase inhibitory activity.

Discovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase

2,3,4,5-Tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepines were found to be potent inhibitors of farnesyltransferase (FT). A hydrophobic substituent at the 4-position of the benzodiazepine, linked via a hydrogen bond acceptor, was important to enzyme i