195985-80-9Relevant academic research and scientific papers
Discovery of (R)-7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4- (2-thienysulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity
Hunt,Ding,Batorsky,Bednarz,Bhide,Cho,Chong,Chao,Gullo-Brown,Guo,Soong Hoon Kim,Lee,Leftheris,Miller,Mitt,Patel,Penhallow,Ricca,Rose,Schmidt,Slusarchyk,Vite,Manne
, p. 3587 - 3595 (2007/10/03)
Continuing structure-activity studies were performed on the 2,3,4,5-tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepine farnesyltransferase (FT) inhibitors. These studies demonstrated that a 3(R)-phenylmethyl group, a hydrophilic 7-cyano group, and a 4-s
Inhibitors of farnesyl protein transferase
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, (2008/06/13)
The present invention comprises benzodiazepine compounds having farnesyl transferase inhibitory activity.
