195992-07-5Relevant articles and documents
Synthesis of chromanyl and dihydrobenzofuranyl piperazines
Favor, David A.,Johnson, Douglas S.,Powers, James J.,Li, Tingsheng,Madabattula, Rambabu
, p. 3039 - 3041 (2008/02/06)
The synthesis of a series of regioisomeric chromanyl and dihydrobenzofuranyl piperazines is described.
Palladium-Catalyzed Synthesis of Indoles by Reductive N-Heteroannulation of 2-Nitrostyrenes
So?derberg, Bjo?rn C.,Shriver, James A.
, p. 5838 - 5845 (2007/10/03)
A palladium-phosphine catalyzed reductive N-heteroannulation of 2-nitrostyrenes, in the presence of carbon monoxide, producing indoles has been developed. Indoles were obtained, in moderate to excellent yield, from substituted 2-nitrostyrenes having either electron-withdrawing (NO2 and CO2-Me) or electron-donating (Br, OH, Me, OMe, and OTf) substituents on the aromatic ring. Best results were obtained using palladium diacetate (6 mol percent) together with triphenylphosphine (24 mol percent) as the catalytic system, under 4 atm of carbon monoxide in acetonitrile at 70 °C. Other palladium(II) and palladium(0) complexes also catalyze the reaction.
