195992-07-5Relevant academic research and scientific papers
Synthesis of chromanyl and dihydrobenzofuranyl piperazines
Favor, David A.,Johnson, Douglas S.,Powers, James J.,Li, Tingsheng,Madabattula, Rambabu
, p. 3039 - 3041 (2008/02/06)
The synthesis of a series of regioisomeric chromanyl and dihydrobenzofuranyl piperazines is described.
Ortho-vinylation reaction of phenols with ethyne
Yamaguchi, Masahiko,Arisawa, Mieko,Omata, Kenji,Kabuto, Kuninobu,Hirama, Masahiro,Uchimaru, Tadafumi
, p. 7298 - 7305 (2007/10/03)
Phenols were vinylated at the ortho-position with ethyne in the presence of SnCl4-Bu3N reagent. The reaction was applicable to phenols possessing either electron-donating or electron-withdrawing groups. 2,6-Divinylphenols were synthe
Palladium-Catalyzed Synthesis of Indoles by Reductive N-Heteroannulation of 2-Nitrostyrenes
So?derberg, Bjo?rn C.,Shriver, James A.
, p. 5838 - 5845 (2007/10/03)
A palladium-phosphine catalyzed reductive N-heteroannulation of 2-nitrostyrenes, in the presence of carbon monoxide, producing indoles has been developed. Indoles were obtained, in moderate to excellent yield, from substituted 2-nitrostyrenes having either electron-withdrawing (NO2 and CO2-Me) or electron-donating (Br, OH, Me, OMe, and OTf) substituents on the aromatic ring. Best results were obtained using palladium diacetate (6 mol percent) together with triphenylphosphine (24 mol percent) as the catalytic system, under 4 atm of carbon monoxide in acetonitrile at 70 °C. Other palladium(II) and palladium(0) complexes also catalyze the reaction.
